Polygenic Score (PGS) ID: PGS001021

Predicted Trait
Reported Trait Feelings of worry or anxiety
Mapped Trait(s)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN1980
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN1980
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 9,747
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
263,546 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 152,035 cases
  • , 111,511 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007868 PSS003642|
African Ancestry|
6,104 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.60438 [0.59021, 0.61855] R²: 0.04352
Incremental AUROC (full-covars): -0.00571
PGS R2 (no covariates): 0.00129
PGS AUROC (no covariates): 0.51656 [0.50201, 0.53111]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007869 PSS003643|
East Asian Ancestry|
1,544 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.58907 [0.5608, 0.61733] R²: 0.03544
Incremental AUROC (full-covars): 0.01078
PGS R2 (no covariates): 0.0074
PGS AUROC (no covariates): 0.54082 [0.51208, 0.56956]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007870 PSS003644|
European Ancestry|
24,170 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.6078 [0.60064, 0.61496] R²: 0.04664
Incremental AUROC (full-covars): 0.01418
PGS R2 (no covariates): 0.01254
PGS AUROC (no covariates): 0.55518 [0.54786, 0.56249]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007871 PSS003645|
South Asian Ancestry|
7,170 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.59978 [0.58669, 0.61287] R²: 0.03875
Incremental AUROC (full-covars): -0.00373
PGS R2 (no covariates): 0.00244
PGS AUROC (no covariates): 0.5253 [0.51187, 0.53873]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007872 PSS003646|
European Ancestry|
65,798 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.6164 [0.61209, 0.62072] R²: 0.05295
Incremental AUROC (full-covars): 0.0259
PGS R2 (no covariates): 0.01465
PGS AUROC (no covariates): 0.55972 [0.5553, 0.56414]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003644 — —
[
  • 13,973 cases
  • , 10,197 controls
]
 — European non-white British ancestry UKB —
PSS003645 — —
[
  • 3,970 cases
  • , 3,200 controls
]
 — South Asian — UKB —
PSS003646 — —
[
  • 37,860 cases
  • , 27,938 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS003642 — —
[
  • 2,702 cases
  • , 3,402 controls
]
 — African unspecified — UKB —
PSS003643 — —
[
  • 746 cases
  • , 798 controls
]
 — East Asian — UKB —