| Predicted Trait | |
| Reported Trait | Volume of grey matter in Parahippocampal Gyrus, anterior division (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25849 |
| Score Construction | |
| PGS Name | GBE_INI25849 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,250 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006755 | PSS006596| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (R) | — | — | R²: 0.33626 [0.31755, 0.35497] Incremental R2 (full-covars): -0.01142 PGS R2 (no covariates): 0.00704 [0.00299, 0.01109] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006756 | PSS006597| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (R) | — | — | R²: 0.24194 [0.2066, 0.27727] Incremental R2 (full-covars): -0.02249 PGS R2 (no covariates): 0.00714 [-0.00081, 0.01509] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006757 | PSS006598| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (R) | — | — | R²: 0.22814 [0.21898, 0.2373] Incremental R2 (full-covars): 0.01288 PGS R2 (no covariates): 0.00762 [0.00547, 0.00977] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006758 | PSS006599| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (R) | — | — | R²: 0.25962 [0.24292, 0.27632] Incremental R2 (full-covars): 0.00817 PGS R2 (no covariates): 0.00943 [0.00517, 0.01369] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006759 | PSS006600| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (R) | — | — | R²: 0.21452 [0.20903, 0.22001] Incremental R2 (full-covars): 0.01002 PGS R2 (no covariates): 0.01016 [0.00866, 0.01167] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006596 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006597 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006598 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006599 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006600 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |