Polygenic Score (PGS) ID: PGS001946

Predicted Trait
Reported Trait C-reactive protein
Mapped Trait(s) C-reactive protein measurement (EFO_0004458)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_CRP
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 71,444
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010443 PSS009430|
European Ancestry|
18,962 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.3858 [0.3736, 0.3978] sex, age, birth date, deprivation index, 16 PCs —
PPM010444 PSS009204|
European Ancestry|
3,944 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.3769 [0.3497, 0.4034] sex, age, birth date, deprivation index, 16 PCs —
PPM010445 PSS008758|
European Ancestry|
6,308 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.3495 [0.3276, 0.371] sex, age, birth date, deprivation index, 16 PCs —
PPM010446 PSS008532|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.3484 [0.2954, 0.3991] sex, age, birth date, deprivation index, 16 PCs —
PPM010447 PSS008310|
South Asian Ancestry|
5,978 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.3629 [0.3406, 0.3847] sex, age, birth date, deprivation index, 16 PCs —
PPM010448 PSS008087|
East Asian Ancestry|
1,710 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.3027 [0.2588, 0.3454] sex, age, birth date, deprivation index, 16 PCs —
PPM010449 PSS007874|
African Ancestry|
2,339 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.215 [0.1758, 0.2534] sex, age, birth date, deprivation index, 16 PCs —
PPM010450 PSS008978|
African Ancestry|
3,653 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: C-reactive protein — — Partial Correlation (partial-r): 0.1982 [0.1667, 0.2292] sex, age, birth date, deprivation index, 16 PCs —
PPM038556 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.02744 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008978 — — 3,653 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009204 — — 3,944 individuals — European Poland (NE Europe) UKB —
PSS008532 — — 1,124 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009430 — — 18,962 individuals — European UK (+ Ireland) UKB —
PSS008758 — — 6,308 individuals — European Italy (South Europe) UKB —
PSS008310 — — 5,978 individuals — South Asian India (South Asia) UKB —
PSS008087 — — 1,710 individuals — East Asian China (East Asia) UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —
PSS007874 — — 2,339 individuals — African American or Afro-Caribbean Carribean UKB —