Polygenic Score (PGS) ID: PGS002208

Predicted Trait
Reported Trait Monocyte percentage
Mapped Trait(s) monocyte percentage of leukocytes (EFO_0007989)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_monocyte_perc
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 544,905
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012511 PSS009474|
European Ancestry|
19,244 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4079 [0.396, 0.4196] sex, age, birth date, deprivation index, 16 PCs —
PPM012512 PSS009248|
European Ancestry|
3,963 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3935 [0.3668, 0.4196] sex, age, birth date, deprivation index, 16 PCs —
PPM012513 PSS008802|
European Ancestry|
6,368 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3978 [0.3769, 0.4183] sex, age, birth date, deprivation index, 16 PCs —
PPM012514 PSS008576|
Greater Middle Eastern Ancestry|
1,144 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.4047 [0.3546, 0.4524] sex, age, birth date, deprivation index, 16 PCs —
PPM012516 PSS008131|
East Asian Ancestry|
1,744 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3023 [0.2587, 0.3445] sex, age, birth date, deprivation index, 16 PCs —
PPM012517 PSS007918|
African Ancestry|
2,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.1887 [0.1488, 0.228] sex, age, birth date, deprivation index, 16 PCs —
PPM012518 PSS009022|
African Ancestry|
3,663 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.1635 [0.1317, 0.1949] sex, age, birth date, deprivation index, 16 PCs —
PPM012515 PSS008354|
South Asian Ancestry|
6,010 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte percentage — — Partial Correlation (partial-r): 0.3313 [0.3085, 0.3536] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009474 — — 19,244 individuals — European UK (+ Ireland) UKB —
PSS007918 — — 2,298 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009248 — — 3,963 individuals — European Poland (NE Europe) UKB —
PSS009022 — — 3,663 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008576 — — 1,144 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008354 — — 6,010 individuals — South Asian India (South Asia) UKB —
PSS008802 — — 6,368 individuals — European Italy (South Europe) UKB —
PSS008131 — — 1,744 individuals — East Asian China (East Asia) UKB —