Polygenic Score (PGS) ID: PGS002296

Predicted Trait
Reported Trait Hypertension
Mapped Trait(s) hypertension (EFO_0000537)
Released in PGS Catalog: May 18, 2022
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Score Details

Score Construction
PGS Name PRS2166_HT
Development Method
Name Clumping and Thresholding (C+T)
Parameters p<6.46E-21, r2=9.46%
Variants
Original Genome Build NR
Number of Variants 2,166
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000326
Citation (link to publication) Maj C et al. Front Cardiovasc Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
458,554 individuals (100%)
Score Development/Training
European: 100%
1,292 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007610
Europe PMC: 30940143
 458,554 individuals European CARDIoGRAMplusC4D, UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 561 cases
  • , 731 controls
]
,
66.0 % Male samples
 European
(Italian)		 HYPERGENES — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013025 PSS009654|
European Ancestry|
2,244 individuals
 PGP000326 |
Maj C et al. Front Cardiovasc Med (2022)
 Reported Trait: Hypertension OR: 3.22 [2.06, 5.1] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009654 — —
[
  • 1,284 cases
  • , 960 controls
]
,
61.0 % Male samples
 — European — NR —