Polygenic Score (PGS) ID: PGS002297

Predicted Trait
Reported Trait Lipoprotein A levels
Mapped Trait(s) lipoprotein A measurement (EFO_0006925)
Released in PGS Catalog: May 18, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS48_lpa
Development Method
Name Genome-wide significant variants
Parameters joint model after stepwise conditional analysis
Variants
Original Genome Build GRCh37
Number of Variants 48
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000327
Citation (link to publication) Coassin S et al. Circ Genom Precis Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
13,781 individuals (100%)
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004398
Europe PMC: 28512139
 13,781 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013026 PSS009655|
Ancestry Not Reported|
22 individuals
 PGP000327 |
Coassin S et al. Circ Genom Precis Med (2022)
 Reported Trait: Lipoprotein (a) levels — — R²: 0.53 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009655 — — 22 individuals,
50.0 % Male samples
 — Not reported — NR —