Polygenic Score (PGS) ID: PGS002794

Predicted Trait
Reported Trait Venous thromboembolism
Mapped Trait(s) venous thromboembolism (EFO_0004286)
Released in PGS Catalog: Oct. 19, 2022
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Score Details

Score Construction
PGS Name PRS_VTE
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 10
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000375
Citation (link to publication) Xie J et al. J Thromb Haemost (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
60,139 individuals (100%)
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002808
Europe PMC: 25772935
 60,139 individuals European 11 cohorts
  • ARIC
  • ,CHS
  • ,EOVT
  • ,GIFT
  • ,HPFS
  • ,HVH
  • ,MARTHA
  • ,Mayo_VTE
  • ,NHS
  • ,NHS2
  • ,WGHS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015496 PSS009962|
Ancestry Not Reported|
359,310 individuals
 PGP000375 |
Xie J et al. J Thromb Haemost (2022)
 Reported Trait: Incident venous thromboembolism witihin 28 days after first dose of COVID-19 vaccination HR: 1.38 [1.13, 1.7] — — Age (at the index date), sex, and genetic ancestry (quantified by the first ten principal components —
PPM015497 PSS009962|
Ancestry Not Reported|
359,310 individuals
 PGP000375 |
Xie J et al. J Thromb Haemost (2022)
 Reported Trait: Incident venous thromboembolism witihin 90 days after first dose of COVID-19 vaccination HR: 1.34 [1.2, 1.5] — — Age (at the index date), sex, and genetic ancestry (quantified by the first ten principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009962 — — 359,310 individuals,
44.6 % Male samples
 Mean = 69.05 years
Sd = 8.04 years		 Not reported — UKB —