Polygenic Score (PGS) ID: PGS003452

Predicted Trait
Reported Trait Waldenström macroglobulinemia
Mapped Trait(s) Waldenstrom macroglobulinemia (EFO_0009441)
Released in PGS Catalog: March 24, 2023
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Score Details

Score Construction
PGS Name PRS2_WM
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 2
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000448
Citation (link to publication) Berndt SI et al. Leukemia (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
4,015 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006982
Europe PMC: 30305637
 4,015 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017228 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Chronic lymphocytic leukemia OR: 1.07 [1.01, 1.14] — — — —
PPM017236 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Diffuse large B-cell lymphoma OR: 1.24 [1.18, 1.31] — — — —
PPM017244 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Follicular lymphoma OR: 1.12 [1.05, 1.19] — — — —
PPM017252 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Marginal zone lymphoma OR: 1.18 [1.07, 1.3] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010176 — —
[
  • 10,629 cases
  • , 9,505 controls
]
 — European — NR Inter- Lymph Consortium