Polygenic Score (PGS) ID: PGS003558

Predicted Trait
Reported Trait Hair/balding pattern
Mapped Trait(s) balding measurement (EFO_0007825)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-M_less_hair
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. Nature (2023)
Ancestry Distribution
Score Development/Training
European: 100%
170,162 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 170,162 individuals,
100.0 % Male samples
 European UKB — Mean = 57.1 years
Sd = 8.1 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017486 PSS010924|
European Ancestry|
9,180 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.23 sex, age, deprivation index, PC1-16 —
PPM017570 PSS010840|
European Ancestry|
1,538 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.23 sex, age, deprivation index, PC1-16 —
PPM017654 PSS010672|
European Ancestry|
2,874 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.21 sex, age, deprivation index, PC1-16 —
PPM017738 PSS010588|
Greater Middle Eastern Ancestry|
669 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017822 PSS010252|
European Ancestry|
1,045 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.19 sex, age, deprivation index, PC1-16 —
PPM017906 PSS010504|
South Asian Ancestry|
3,222 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.13 sex, age, deprivation index, PC1-16 —
PPM017990 PSS010420|
East Asian Ancestry|
574 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.08 sex, age, deprivation index, PC1-16 —
PPM018074 PSS010336|
African Ancestry|
838 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM018158 PSS010756|
African Ancestry|
1,707 individuals
 PGP000457 |
Ding Y et al. Nature (2023)
 Reported Trait: Hair/balding pattern — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010336 — — 838 individuals,
100.0 % Male samples
 Mean = 52.8 years
Sd = 8.4 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010756 — — 1,707 individuals,
100.0 % Male samples
 Mean = 51.3 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010504 — — 3,222 individuals,
100.0 % Male samples
 Mean = 53.6 years
Sd = 8.7 years		 South Asian Indian UKB —
PSS010252 — — 1,045 individuals,
100.0 % Male samples
 Mean = 58.4 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS010924 — — 9,180 individuals,
100.0 % Male samples
 Mean = 57.1 years
Sd = 8.0 years		 European white British UKB —
PSS010672 — — 2,874 individuals,
100.0 % Male samples
 Mean = 54.8 years
Sd = 8.5 years		 European Italian UKB —
PSS010420 — — 574 individuals,
100.0 % Male samples
 Mean = 52.3 years
Sd = 8.2 years		 East Asian Chinese UKB —
PSS010840 — — 1,538 individuals,
100.0 % Male samples
 Mean = 54.1 years
Sd = 7.4 years		 European Polish UKB —
PSS010588 — — 669 individuals,
100.0 % Male samples
 Mean = 51.9 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —