Polygenic Score (PGS) ID: PGS003754

Predicted Trait
Reported Trait Nonmucinous Epithelial Ovarian Cancer
Mapped Trait(s) ovarian carcinoma (EFO_0001075)
Released in PGS Catalog: June 22, 2023
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Score Details

Score Construction
PGS Name PRS22_OCstepwise
Development Method
Name Stepwise method
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 22
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000474
Citation (link to publication) Hurwitz LM et al. JAMA Netw Open (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
63,702 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 35027648
[
  • 23,564 cases
  • , 40,138 controls
]
 European OCAC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018518 PSS011005|
Multi-ancestry (including European)|
11,135 individuals
 PGP000474 |
Hurwitz LM et al. JAMA Netw Open (2023)
 Reported Trait: Nonmucinous Epithelial Ovarian Cancer x aspirin use interaction — — Odds ratio (OR, <median): 0.85 [0.7, 1.02]
Odds ratio (OR, >=median): 0.86 [0.74, 1.01]		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011005 — —
[
  • 122 cases
  • , 218 controls
]
 — African American or Afro-Caribbean
(Black)		 — OCAC —
PSS011005 — —
[
  • 3,995 cases
  • , 5,851 controls
]
 — European — OCAC —
PSS011005 — —
[
  • 359 cases
  • , 590 controls
]
 — Not reported — OCAC —