Polygenic Score (PGS) ID: PGS003859

Predicted Trait
Reported Trait Insomnia
Mapped Trait(s) insomnia measurement (EFO_0007876)
Released in PGS Catalog: Sept. 1, 2023
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS129_insomnia
Development Method
Name Genome-wide significant SNPs
Parameters R2>0.001
Variants
Original Genome Build NR
Number of Variants 129
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000497
Citation (link to publication) Gibson MJ et al. BMC Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,331,010 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007988
Europe PMC: 30804565
 1,331,010 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018713 PSS011077|
European Ancestry|
336,975 individuals
 PGP000497 |
Gibson MJ et al. BMC Med (2023)
 Reported Trait: Insomnia symptoms (usually vs never/rarely/sometimes having trouble falling or staying asleep) OR: 1.08 [1.07, 1.09] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011077 — — 336,975 individuals,
46.0 % Male samples
 — European — UKB —