Polygenic Score (PGS) ID: PGS003862

Predicted Trait
Reported Trait Lung function (FEV1/FVC)
Mapped Trait(s) FEV/FVC ratio (EFO_0004713)
Released in PGS Catalog: Sept. 1, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name multiancestry_LF_GRS_FF_weights_EUR
Development Method
Name GRS (weights estimated from MR.MEGA)
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 442
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000500
Citation (link to publication) Shrine N et al. Nat Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
149,166 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90244093
 149,166 individuals European 31 cohorts
  • AHS
  • ,ALSPAC
  • ,ARIC
  • ,B58C
  • ,BHS
  • ,CHS
  • ,CROATIA-KORCULA
  • ,CROATIA-SPLIT
  • ,CROATIA-VIS
  • ,EPIC-Norfolk
  • ,EXCEED
  • ,FHS
  • ,FTC
  • ,GS:SFHS
  • ,HUNT
  • ,Health2000
  • ,KORA
  • ,LBC
  • ,MESA
  • ,NEO
  • ,NFBC
  • ,ORCADES
  • ,PIVUS
  • ,RAINE
  • ,RS
  • ,SAPALDIA
  • ,SHIP
  • ,TwinsUK
  • ,UKHLS
  • ,VIKING
  • ,YFS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018752 PSS011096|
European Ancestry|
320,656 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: FEV1/FVC ratio β: 0.2787 [0.2753, 0.282] — — age, age^2, sex, height, smoking, 10 genetic PCs Beta = Standard deviation (SD) change of FEV1/FVC per SD change of GRS
PPM018756 PSS011092|
European Ancestry|
11,074 individuals
 PGP000500 |
Shrine N et al. Nat Genet (2023)
 Reported Trait: Chronic obstructive pulmonary disease OR: 1.63 [1.56, 1.71] — — age, age^2, sex, height, smoking —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011096 — — 320,656 individuals — European — UKB —
PSS011092 — —
[
  • 6,746 cases
  • , 4,328 controls
]
 — European — 6 cohorts
  • COPDGene
  • ,ECLIPSE
  • ,GenKOLS
  • ,NAS
  • ,NETT
  • ,SPIROMICS
 —