Polygenic Score (PGS) ID: PGS004319

Predicted Trait
Reported Trait Body mass index
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name GRS103_BMI
Development Method
Name Genome-wide significant SNPs
Parameters information quality >0.8, MAF >1%, p < .05/103 or .0005
Variants
Original Genome Build NR
Number of Variants 103
Effect Weight Type Unweighted
PGS Source
PGS Catalog Publication (PGP) ID PGP000549
Citation (link to publication) Fernández-Rhodes L et al. Psychosom Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 90.1%
African: 9.6%
Hispanic or Latin American: 0.3%
418,021 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST001955
Europe PMC: 23563607
 16,068 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 236,781 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 887 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 1,276 individuals Hispanic or Latin American NR
GWAS Catalog: GCST001967
Europe PMC: 23583978
 37,956 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST001967
Europe PMC: 23583978
 1,188 individuals Sub-Saharan African NR
GWAS Catalog: GCST000830
Europe PMC: 20935630
 123,865 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020403 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index — — Beta (per effect allele): 0.34 — —
PPM020404 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index in females — — Beta (per effect allele): 0.37 — —
PPM020405 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index in males — — Beta (per effect allele): 0.27 — —
PPM020406 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x SASH language use subscale interaction — — Beta (per effect allele): 0.17 (0.02) age, sex, top 5 principal components, and study site —
PPM020407 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x SASH language use subscale interaction in females — — Beta (per effect allele): 0.15 (0.03) age, sex, top 5 principal components, and study site —
PPM020408 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x SASH language use subscale interaction in males — — Beta (per effect allele): 0.22 (0.03) age, sex, top 5 principal components, and study site —
PPM020409 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x nativity interaction — — Beta (per effect allele): 0.19 (0.03) age, sex, top 5 principal components, and study site —
PPM020410 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x nativity interaction in females — — Beta (per effect allele): 0.23 (0.04) age, sex, top 5 principal components, and study site —
PPM020411 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x nativity interaction in males — — Beta (per effect allele): 0.15 (0.03) age, sex, top 5 principal components, and study site —
PPM020412 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x time in United States interaction — — Beta (per effect allele): 0.09 (0.01) age, sex, top 5 principal components, and study site —
PPM020413 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x time in United States interaction in females — — Beta (per effect allele): 0.11 (0.01) age, sex, top 5 principal components, and study site —
PPM020414 PSS011351|
Hispanic or Latin American Ancestry|
11,747 individuals
 PGP000549 |
Fernández-Rhodes L et al. Psychosom Med (2023)
 Reported Trait: Body mass index x time in United States interaction in males — — Beta (per effect allele): 0.06 (0.01) age, sex, top 5 principal components, and study site —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011351 — — 11,747 individuals,
49.1 % Male samples
 Mean = 43.0 years Hispanic or Latin American — HCHS-SOL —