Polygenic Score (PGS) ID: PGS004898

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: May 8, 2024
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Score Details

Score Construction
PGS Name PRS_AD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 44
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000624
Citation (link to publication) Vasiljevic E et al. Alzheimers Dement (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
409,435 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST012182
Europe PMC: 34099642
 409,435 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021281 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Immediate learning β: -0.07 [-0.12, -0.02] — — Sex, years of education, testing practice effects —
PPM021282 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Delayed recall β: -0.07 [-0.12, -0.02] — — Sex, years of education, testing practice effects —
PPM021283 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Executive function β: -0.06 [-0.11, -0.01] — — Sex, years of education, testing practice effects —
PPM021284 PSS011676|
European Ancestry|
1,135 individuals
 PGP000624 |
Vasiljevic E et al. Alzheimers Dement (2023)
 Reported Trait: Preclinical Alzheimer Cognitive Composite (PACC3) β: -0.08 [-0.13, -0.04] — — Sex, years of education, testing practice effects —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011676 — — 1,135 individuals,
30.0 % Male samples
 Mean = 59.0 years
Sd = 6.0 years		 European — WRAP —