Polygenic Score (PGS) ID: PGS005096

Predicted Trait
Reported Trait Coronary artery calcification
Mapped Trait(s) coronary artery calcification (EFO_0004723)
Released in PGS Catalog: Nov. 21, 2024
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Score Details

Score Construction
PGS Name CAC_GRS
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 11
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000689
Citation (link to publication) Mishra PP et al. Am J Prev Cardiol (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 78%
African: 22%
36,720 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90278455
Europe PMC: 37770635
 28,655 individuals European 14 cohorts
  • AGES
  • ,ASPS
  • ,CARDIA
  • ,COPDGene
  • ,DiabHS
  • ,FHS
  • ,FamHS
  • ,GENOA
  • ,GeneSTAR
  • ,JHS
  • ,LLS
  • ,MESA
  • ,NELSON
  • ,YFS
GWAS Catalog: GCST90278455
Europe PMC: 37770635
 8,065 individuals African American or Afro-Caribbean 14 cohorts
  • AGES
  • ,ASPS
  • ,CARDIA
  • ,COPDGene
  • ,DiabHS
  • ,FHS
  • ,FamHS
  • ,GENOA
  • ,GeneSTAR
  • ,JHS
  • ,LLS
  • ,MESA
  • ,NELSON
  • ,YFS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022192 PSS011838|
European Ancestry|
2,742 individuals
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Reported Trait: Coronary artery disease OR: 1.41 [1.28, 1.55] — — Age, sex, systolic blood pressure, total cholesterol, HDL cholesterol, smoking status, hypertension medication, 5 PCs —
PPM022193 PSS011839|
European Ancestry|
622 individuals
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Reported Trait: Coronary artery disease OR: 4.2 [1.74, 10.52] — — Age, sex, BMI, smoking status, hypertension medication, 5 PCs —
PPM022194 PSS011840|
European Ancestry|
133 individuals
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Reported Trait: Coronary artery disease OR: 1.79 [1.05, 3.21] — — Age, sex, systolic blood pressure, total cholesterol, HDL cholesterol, smoking status, hypertension medication, 5 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011839 — —
[
  • 327 cases
  • , 295 controls
]
,
75.0 % Male samples
 — European — TSDS —
PSS011840 — —
[
  • 98 cases
  • , 35 controls
]
,
71.0 % Male samples
 — European — TVS —
PSS011838 — —
[
  • 1,912 cases
  • , 830 controls
]
,
71.0 % Male samples
 — European — LURIC —