Polygenic Score (PGS) ID: PGS005198

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: July 24, 2025
Download Score FTP directory
Terms and Licenses
Creative Commons Attribution 4.0 International (CC BY 4.0).

Score Details

Score Construction
PGS Name GIANT_BMI_2025_PRSCS
Development Method
Name PRS-CS
Parameters This score was generated using PRS-CS with default settings and its --AUTO option, based on a multi-ancestral GWAS meta-analysis (AMR, AFR, EAS, EUR, and SAS combined) combined with a previously described multi-ancestry 1000G-based LD reference panel (PMID: 34887591). Variants were filtered to those with MAF≥0.1% and INFO≥0.8 in the overall UK Biobank.
Variants
Original Genome Build hg19
Number of Variants 1,217,710
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000724
Citation (link to publication) Smit RAJ et al. Nat Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • African
  • Hispanic or Latin American
  • East Asian
  • European
  • South Asian
1,630,000 individuals (100%)
PGS Evaluation
African: 25%
Hispanic or Latin American: 25%
Additional Asian Ancestries: 25%
European: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 1,630,000 individuals African unspecified, Hispanic or Latin American, East Asian, European, South Asian 203 cohorts
  • ABDC
  • ,AEB
  • ,AEGS1
  • ,AFLMU
  • ,AFNET
  • ,AGES
  • ,AIDHS
  • ,AMFS
  • ,ARIC
  • ,ASCOT
  • ,ASPS
  • ,AugUR
  • ,B-PROOF
  • ,B58C
  • ,BBJ
  • ,BBM
  • ,BCAC
  • ,BES
  • ,BMDCS
  • ,BMES
  • ,BRIGHT
  • ,BioMe
  • ,BioVU
  • ,CAGE
  • ,CAGE-Amagasaki
  • ,CAGE-KING
  • ,CARDIA
  • ,CARDIOGENICS
  • ,CATHGEN
  • ,CFS
  • ,CHIP
  • ,CHNS
  • ,CHOP
  • ,CHRIS
  • ,CHS
  • ,CKB
  • ,CLHNS
  • ,CTMM
  • ,Cilento
  • ,CoLaus
  • ,DCS
  • ,DGI
  • ,DIACORE
  • ,DNBC
  • ,Danfund
  • ,EPIC
  • ,EPIC-Potsdam
  • ,EPOZ
  • ,ERF
  • ,EUGENDA
  • ,EWUH-PCOS
  • ,EXTEND
  • ,EpiHealth
  • ,FHS
  • ,FINCAVAS
  • ,FINRISK
  • ,FTC
  • ,FUSION
  • ,FamHS
  • ,Fenland
  • ,GAF
  • ,GCKD
  • ,GENOA
  • ,GEOS
  • ,GFG
  • ,GGAF
  • ,GLACIER
  • ,GOLDN
  • ,GOMAP
  • ,GRADE
  • ,GRAPHIC
  • ,GRMIC
  • ,GS:SFHS
  • ,GeneRISK
  • ,GerMIFS
  • ,GoDARTS
  • ,HABC
  • ,HANDLS
  • ,HCHS-SOL
  • ,HCS
  • ,HELIC
  • ,HNR
  • ,HPFS
  • ,HRS
  • ,HUNT
  • ,HYPERGEN
  • ,Health2006
  • ,Health2008
  • ,Health2010
  • ,HealthABC
  • ,Hoorn study
  • ,IHCS
  • ,IMHS
  • ,INDICO
  • ,INGI-FVG
  • ,InCHIANTI
  • ,Inter99
  • ,JHS
  • ,JHU-AF
  • ,JOCO
  • ,JPDSC
  • ,JUPITER
  • ,KARE
  • ,KODGP
  • ,KORA
  • ,KSCS
  • ,LEI
  • ,LIFE-Adult
  • ,LLFS
  • ,LOLIPOP
  • ,LURIC
  • ,Living-Biobank
  • ,MC
  • ,MCTFR
  • ,MESA
  • ,METSIM
  • ,MGH-AF
  • ,MGH-CMPC
  • ,MGH-CNC
  • ,MGH-stroke
  • ,MGI
  • ,MHC
  • ,MHI
  • ,MIGen
  • ,MPP-AF
  • ,MPP-echo
  • ,MVP
  • ,Maywood
  • ,MrOS
  • ,MyCode
  • ,NAFLD BioResource
  • ,NBS
  • ,NEO
  • ,NESCOG
  • ,NESDA
  • ,NFBC
  • ,NHAPC
  • ,NHS
  • ,NHS2
  • ,NICOLA
  • ,NIHR BIORESOURCE
  • ,NSHD
  • ,NTR
  • ,Nagahama_Study
  • ,Nigeria
  • ,OBB
  • ,OGP
  • ,ORCADES
  • ,PARC
  • ,PEGASUS_PCa
  • ,PHS
  • ,PMB
  • ,POPGEN
  • ,PRACTICAL
  • ,PREVEND
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,QFS
  • ,QIMR-BGE
  • ,RHS
  • ,RISC
  • ,ROSMAP
  • ,RS
  • ,SBCS
  • ,SCES
  • ,SCHS
  • ,SDC
  • ,SDCC
  • ,SHIP
  • ,SIGMA
  • ,SIMES
  • ,SINDI
  • ,SORBS
  • ,SP2
  • ,STRIP
  • ,SWHS
  • ,SardiNIA
  • ,SiDS
  • ,Silk Road
  • ,T-6M
  • ,TGS
  • ,THISEAS
  • ,THRV
  • ,TRAILS
  • ,TRAILSCC
  • ,TRS
  • ,TwinGene
  • ,TwinsUK
  • ,UCS-AF
  • ,UKHLS
  • ,VAFAR
  • ,VDB
  • ,VIKING
  • ,VIS
  • ,WFSM
  • ,WGHS
  • ,WHI
  • ,WHI-GARNET
  • ,WHI-LLS
  • ,WMUB-T
  • ,YACDS
  • ,YFS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022558 PSS012014|
Additional Asian Ancestries|
1,299 individuals
 PGP000724 |
Smit RAJ et al. Nat Med (2025)
 Reported Trait: Obesity class I, or higher (BMI ≥27.5 kg/m2) [Asian specific] OR: 5.73 [2.28, 14.57] — — age, sex, 4 PCs OR [95%CI] is for top 3% of score, adjusting for the covariates
PPM022556 PSS012013|
Hispanic or Latin American Ancestry|
4,710 individuals
 PGP000724 |
Smit RAJ et al. Nat Med (2025)
 Reported Trait: Obesity class I, or higher (BMI ≥30 kg/m2) OR: 2.33 [1.64, 3.31] — — age, sex, 4 PCs OR [95%CI] is for top 3% of score, adjusting for the covariates
PPM022555 PSS012012|
African Ancestry|
3,215 individuals
 PGP000724 |
Smit RAJ et al. Nat Med (2025)
 Reported Trait: Obesity class I, or higher (BMI ≥30 kg/m2) OR: 2.54 [1.55, 3.98] — — age, sex, 4 PCs OR [95%CI] is for top 3% of score, adjusting for the covariates
PPM022557 PSS012015|
European Ancestry|
6,134 individuals
 PGP000724 |
Smit RAJ et al. Nat Med (2025)
 Reported Trait: Obesity class I, or higher (BMI ≥30 kg/m2) OR: 4.08 [3.02, 5.52] — — age, sex, 4 PCs OR [95%CI] is for top 3% of score, adjusting for the covariates

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012012 — —
[
  • 1,396 cases
  • , 1,819 controls
]
 — African American or Afro-Caribbean — BioMe —
PSS012013 — —
[
  • 1,821 cases
  • , 2,889 controls
]
 — Hispanic or Latin American — BioMe —
PSS012014 — —
[
  • 282 cases
  • , 1,017 controls
]
 — Asian unspecified — BioMe —
PSS012015 — —
[
  • 1,226 cases
  • , 4,908 controls
]
 — European — BioMe —