| Predicted Trait | |
| Reported Trait | Ischemic stroke |
| Mapped Trait(s) | Ischemic stroke (HP_0002140) |
| Score Construction | |
| PGS Name | IS_PRSCS_HM3_EUR |
| Development Method | |
| Name | PRS-CS |
| Parameters | phi=1E-02, HapMap3 reference panel |
| Variants | |
| Original Genome Build | GRCh38 |
| Number of Variants | 1,093,847 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000839 |
| Citation (link to publication) | Armstrong ND et al. Front Bioinform (2026) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST90104540 Europe PMC: 36180795 |
1,296,908 individuals | European | Multiple |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | [ ,
57.7 % Male samples |
European | REGARDS | — | Mean = 68.3 years Sd = 10.4 years |
— | — | ischemic stroke - ischemic stroke events in REGARDS were identified through biannual surveillance and adjudicated via medical record review. For participants aligned to Medicare claims, additional ischemic stroke events were identified from inpatient claims using ICD-9 codes 433.x1 or 434.x1 or ICD-10 codes I63.xx in the primary diagnosis position. Hospitalizations occurring within one day of each other were merged into a single episode of care. Participants with self-reported stroke at baseline were excluded. |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM038128 | PSS013829| European Ancestry| 78,155 individuals |
PGP000839 | Armstrong ND et al. Front Bioinform (2026) |
Reported Trait: ischemic stroke | OR: 1.105 [1.073, 1.138] | AUROC: 0.66326 | — | age, sex, PC 1-10 | — |
| PPM038134 | PSS013831| European Ancestry| 11,255 individuals |
PGP000839 | Armstrong ND et al. Front Bioinform (2026) |
Reported Trait: ischemic stroke | OR: 1.086 [0.984, 1.197] | AUROC: 0.626 [0.6005, 0.6516] | — | age, sex, PC 1-10 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS013829 | — | — | [ ,
41.8 % Male samples |
Mean = 68.8 years Sd = 10.0 years |
European | — | AllofUs | To harmonize phenotype definitions with REGARDS, analyses in All of Us were restricted to participants aged ≥45 years. IS cases were defined as individuals with an inpatient encounter associated with ICD-9 codes 433.x1 or 434.x1, or ICD-10 codes I63.xx. Stroke codes identified only in non-inpatient encounters, SNOMED stroke codes, and hemorrhagic stroke codes (ICD-9 430.x, 431.x; ICD-10 I60.x, I61.x) were excluded from both case and control sets. |
| PSS013831 | — | — | [ ,
48.4 % Male samples |
Mean = 64.0 years Sd = 9.1 years |
European | — | REGARDS | ischemic stroke - ischemic stroke events in REGARDS were identified through biannual surveillance and adjudicated via medical record review. For participants aligned to Medicare claims, additional ischemic stroke events were identified from inpatient claims using ICD-9 codes 433.x1 or 434.x1 or ICD-10 codes I63.xx in the primary diagnosis position. Hospitalizations occurring within one day of each other were merged into a single episode of care. Participants with self-reported stroke at baseline were excluded. |