PGS Publication: PGP000391

Publication Information (EuropePMC)
Title Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.
PubMed ID 35773277(Europe PMC)
doi 10.1038/s41467-022-30931-2
Publication Date June 30, 2022
Journal Nat Commun
Author(s) Agrawal S, Wang M, Klarqvist MDR, Smith K, Shin J, Dashti H, Diamant N, Choi SH, Jurgens SJ, Ellinor PT, Philippakis A, Claussnitzer M, Ng K, Udler MS, Batra P, Khera AV.
Released in PGS Catalog: Nov. 7, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002811
(ASATadjbmi3_weights_select)
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Abdominal adipose tissue volumes adjusted for BMI and height adipose amount 1,125,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002811/ScoringFiles/PGS002811.txt.gz
PGS002812
(GFATadjbmi3_weights_select)
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Gluteofemoral adipose tissue volumes adjusted for BMI and height adipose amount 1,125,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002812/ScoringFiles/PGS002812.txt.gz
PGS002813
(VATadjbmi3_weights_select)
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Visceral adipose tissue volumes adjusted for BMI and height visceral adipose tissue quantity 1,125,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002813/ScoringFiles/PGS002813.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015599 PGS002813
(VATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 1.18 — —
PPM015600 PGS002813
(VATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Coronary artery disease — — Odds ratio (OR, top 10% vs reminder): 1.12 — —
PPM015601 PGS002813
(VATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Hypertension — — Odds ratio (OR, top 10% vs reminder): 1.09 — —
PPM015586 PGS002813
(VATadjbmi3_weights_select)
 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Visceral adipose tissue volumes adjusted for BMI and height β: 0.221 (0.016) — Odds ratio (OR, top 5% vs reminder): 2.41 [1.7, 3.36] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015587 PGS002811
(ASATadjbmi3_weights_select)
 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Abdominal adipose tissue volumes adjusted for BMI and height β: 0.195 (0.016) — Odds ratio (OR, top 5% vs reminder): 2.13 [1.46, 3.03] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015588 PGS002812
(GFATadjbmi3_weights_select)
 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Gluteofemoral adipose tissue volumes adjusted for BMI and height β: 0.262 (0.016) — Odds ratio (OR, top 5% vs reminder): 3.81 [2.76, 5.17] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015589 PGS002811
(ASATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.09 [0.02, 0.17] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015590 PGS002812
(GFATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.14 [0.07, 0.22] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015591 PGS002812
(GFATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (top 10 % vs reminder): -0.16 [-0.23, -0.08] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015592 PGS002813
(VATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (bottom 10 % vs reminder): -0.12 [-0.19, -0.05] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015593 PGS002812
(GFATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 0.57 [0.41, 0.78] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015594 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.16 [0.15, 0.18] — —
PPM015595 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (top 10 % vs reminder): -0.16 [-0.18, -0.15] — —
PPM015596 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Alanine aminotransferase — — Beta (top 10 % vs reminder): -0.09 [-0.1, -0.07] — —
PPM015597 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 0.75 [0.7, 0.8] — —
PPM015598 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Coronary artery disease — — Odds ratio (OR, top 10% vs reminder): 0.89 [0.85, 0.93] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009992 — — 7,888 individuals — European
(White)		 — ARIC —
PSS009993 — — 7,795 individuals — European, African unspecified, East Asian, South Asian, Not reported White British, Black, East Asian, South Asian, Other UKB 20% of original GWAS cohort
PSS009994 — — 447,486 individuals — European, African unspecified, East Asian, South Asian, Not reported White British, Black, East Asian, South Asian, Other UKB Unimaged cohort of UKB