PGS Publication: PGP000595

Publication Information (EuropePMC)
Title An ensemble penalized regression method for multi-ancestry polygenic risk prediction.
PubMed ID 38622117(Europe PMC)
doi 10.1038/s41467-024-47357-7
Publication Date April 15, 2024
Journal Nat Commun
Author(s) Zhang J, Zhan J, Jin J, Ma C, Zhao R, O'Connell J, Jiang Y, 23andMe Research Team, Koelsch BL, Zhang H, Chatterjee N.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004631
(HDL_EAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,871,796
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004631/ScoringFiles/PGS004631.txt.gz
PGS004632
(HDL_SAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 9,116
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004632/ScoringFiles/PGS004632.txt.gz
PGS004637
(LDL_AFR_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 173
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004637/ScoringFiles/PGS004637.txt.gz
PGS004641
(LDL_AFR_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,879,609
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004641/ScoringFiles/PGS004641.txt.gz
PGS004643
(LDL_EAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,194,231
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004643/ScoringFiles/PGS004643.txt.gz
PGS004658
(logTG_EAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,192,539
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004658/ScoringFiles/PGS004658.txt.gz
PGS004665
(logTG_SAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 298,999
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004665/ScoringFiles/PGS004665.txt.gz
PGS004676
(TC_EAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,872,229
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004676/ScoringFiles/PGS004676.txt.gz
PGS004683
(height_AFR_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Height body height 774,968
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004683/ScoringFiles/PGS004683.txt.gz
PGS004686
(height_AFR_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Height body height 872,587
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004686/ScoringFiles/PGS004686.txt.gz
PGS004661
(logTG_EAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,880,060
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004661/ScoringFiles/PGS004661.txt.gz
PGS004674
(TC_EAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,728,954
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004674/ScoringFiles/PGS004674.txt.gz
PGS004640
(LDL_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 107,449
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004640/ScoringFiles/PGS004640.txt.gz
PGS004644
(LDL_EAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,354,681
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004644/ScoringFiles/PGS004644.txt.gz
PGS004654
(logTG_AFR_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,775,011
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004654/ScoringFiles/PGS004654.txt.gz
PGS004660
(logTG_EAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 298,999
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004660/ScoringFiles/PGS004660.txt.gz
PGS004662
(logTG_SAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 12,717
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004662/ScoringFiles/PGS004662.txt.gz
PGS004666
(logTG_SAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,880,060
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004666/ScoringFiles/PGS004666.txt.gz
PGS004669
(TC_AFR_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,728,954
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004669/ScoringFiles/PGS004669.txt.gz
PGS004671
(TC_AFR_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,872,229
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004671/ScoringFiles/PGS004671.txt.gz
PGS004680
(TC_SAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 158,252
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004680/ScoringFiles/PGS004680.txt.gz
PGS004682
(height_AFR_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Height body height 906
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004682/ScoringFiles/PGS004682.txt.gz
PGS004681
(TC_SAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,872,229
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004681/ScoringFiles/PGS004681.txt.gz
PGS004684
(height_AFR_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Height body height 859,897
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004684/ScoringFiles/PGS004684.txt.gz
PGS004679
(TC_SAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,728,954
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004679/ScoringFiles/PGS004679.txt.gz
PGS004655
(logTG_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 298,999
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004655/ScoringFiles/PGS004655.txt.gz
PGS004656
(logTG_AFR_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,880,060
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004656/ScoringFiles/PGS004656.txt.gz
PGS004675
(TC_EAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 158,252
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004675/ScoringFiles/PGS004675.txt.gz
PGS004678
(TC_SAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,471,975
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004678/ScoringFiles/PGS004678.txt.gz
PGS004638
(LDL_AFR_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,683,941
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004638/ScoringFiles/PGS004638.txt.gz
PGS004639
(LDL_AFR_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,794,429
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004639/ScoringFiles/PGS004639.txt.gz
PGS004645
(LDL_EAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 107,449
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004645/ScoringFiles/PGS004645.txt.gz
PGS004651
(LDL_SAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,879,609
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004651/ScoringFiles/PGS004651.txt.gz
PGS004652
(logTG_AFR_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 446
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004652/ScoringFiles/PGS004652.txt.gz
PGS004664
(logTG_SAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,775,011
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004664/ScoringFiles/PGS004664.txt.gz
PGS004670
(TC_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 158,252
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004670/ScoringFiles/PGS004670.txt.gz
PGS004623
(HDL_AFR_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,683,003
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004623/ScoringFiles/PGS004623.txt.gz
PGS004626
(HDL_AFR_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,871,796
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004626/ScoringFiles/PGS004626.txt.gz
PGS004634
(HDL_SAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,731,178
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004634/ScoringFiles/PGS004634.txt.gz
PGS004648
(LDL_SAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,511,084
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004648/ScoringFiles/PGS004648.txt.gz
PGS004653
(logTG_AFR_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,682,390
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004653/ScoringFiles/PGS004653.txt.gz
PGS004659
(logTG_EAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,722,077
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004659/ScoringFiles/PGS004659.txt.gz
PGS004663
(logTG_SAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 1,510,317
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004663/ScoringFiles/PGS004663.txt.gz
PGS004668
(TC_AFR_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,691,065
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004668/ScoringFiles/PGS004668.txt.gz
PGS004624
(HDL_AFR_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,688,569
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004624/ScoringFiles/PGS004624.txt.gz
PGS004635
(HDL_SAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 291,154
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004635/ScoringFiles/PGS004635.txt.gz
PGS004636
(HDL_SAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,871,796
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004636/ScoringFiles/PGS004636.txt.gz
PGS004642
(LDL_EAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 8,643
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004642/ScoringFiles/PGS004642.txt.gz
PGS004672
(TC_EAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 65,005
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004672/ScoringFiles/PGS004672.txt.gz
PGS004673
(TC_EAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 823,148
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004673/ScoringFiles/PGS004673.txt.gz
PGS004622
(HDL_AFR_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 15,978
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004622/ScoringFiles/PGS004622.txt.gz
PGS004625
(HDL_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 291,154
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004625/ScoringFiles/PGS004625.txt.gz
PGS004627
(HDL_EAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 54,812
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004627/ScoringFiles/PGS004627.txt.gz
PGS004628
(HDL_EAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 847,389
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004628/ScoringFiles/PGS004628.txt.gz
PGS004629
(HDL_EAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,731,178
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004629/ScoringFiles/PGS004629.txt.gz
PGS004630
(HDL_EAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 291,154
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004630/ScoringFiles/PGS004630.txt.gz
PGS004633
(HDL_SAS_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,476,939
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004633/ScoringFiles/PGS004633.txt.gz
PGS004646
(LDL_EAS_weighted_ldpred2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,879,609
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004646/ScoringFiles/PGS004646.txt.gz
PGS004647
(LDL_SAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 307
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004647/ScoringFiles/PGS004647.txt.gz
PGS004649
(LDL_SAS_PROSPER)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,794,429
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004649/ScoringFiles/PGS004649.txt.gz
PGS004650
(LDL_SAS_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 107,449
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004650/ScoringFiles/PGS004650.txt.gz
PGS004657
(logTG_EAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Log triglycerides triglyceride measurement 221
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004657/ScoringFiles/PGS004657.txt.gz
PGS004667
(TC_AFR_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 1,830
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004667/ScoringFiles/PGS004667.txt.gz
PGS004677
(TC_SAS_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Total cholesterol total cholesterol measurement 2,421
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004677/ScoringFiles/PGS004677.txt.gz
PGS004685
(height_AFR_weighted_lassosum2)
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Height body height 279,186
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004685/ScoringFiles/PGS004685.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020856 PGS004671
(TC_AFR_weighted_ldpred2)
 PSS011421|
African Ancestry|
4,302 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.1138 — —
PPM020808 PGS004623
(HDL_AFR_ldpred2)
 PSS011419|
African Ancestry|
3,983 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.0913 — —
PPM020809 PGS004624
(HDL_AFR_PROSPER)
 PSS011419|
African Ancestry|
3,983 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1096 — —
PPM020810 PGS004625
(HDL_AFR_weighted_lassosum2)
 PSS011419|
African Ancestry|
3,983 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.0929 — —
PPM020812 PGS004627
(HDL_EAS_lassosum2)
 PSS011424|
East Asian Ancestry|
892 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1345 — —
PPM020813 PGS004628
(HDL_EAS_ldpred2)
 PSS011424|
East Asian Ancestry|
892 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1197 — —
PPM020814 PGS004629
(HDL_EAS_PROSPER)
 PSS011424|
East Asian Ancestry|
892 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1572 — —
PPM020815 PGS004630
(HDL_EAS_weighted_lassosum2)
 PSS011424|
East Asian Ancestry|
892 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1576 — —
PPM020816 PGS004631
(HDL_EAS_weighted_ldpred2)
 PSS011424|
East Asian Ancestry|
892 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.167 — —
PPM020817 PGS004632
(HDL_SAS_lassosum2)
 PSS011427|
South Asian Ancestry|
4,702 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.094 — —
PPM020818 PGS004633
(HDL_SAS_ldpred2)
 PSS011427|
South Asian Ancestry|
4,702 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1016 — —
PPM020820 PGS004635
(HDL_SAS_weighted_lassosum2)
 PSS011427|
South Asian Ancestry|
4,702 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1423 — —
PPM020821 PGS004636
(HDL_SAS_weighted_ldpred2)
 PSS011427|
South Asian Ancestry|
4,702 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1503 — —
PPM020822 PGS004637
(LDL_AFR_lassosum2)
 PSS011420|
African Ancestry|
4,292 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.141 — —
PPM020823 PGS004638
(LDL_AFR_ldpred2)
 PSS011420|
African Ancestry|
4,292 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.1212 — —
PPM020824 PGS004639
(LDL_AFR_PROSPER)
 PSS011420|
African Ancestry|
4,292 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.1538 — —
PPM020825 PGS004640
(LDL_AFR_weighted_lassosum2)
 PSS011420|
African Ancestry|
4,292 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.1472 — —
PPM020827 PGS004642
(LDL_EAS_lassosum2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0329 — —
PPM020828 PGS004643
(LDL_EAS_ldpred2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0348 — —
PPM020829 PGS004644
(LDL_EAS_PROSPER)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0668 — —
PPM020830 PGS004645
(LDL_EAS_weighted_lassosum2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0805 — —
PPM020831 PGS004646
(LDL_EAS_weighted_ldpred2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0721 — —
PPM020832 PGS004647
(LDL_SAS_lassosum2)
 PSS011428|
South Asian Ancestry|
5,137 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0332 — —
PPM020833 PGS004648
(LDL_SAS_ldpred2)
 PSS011428|
South Asian Ancestry|
5,137 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0343 — —
PPM020835 PGS004650
(LDL_SAS_weighted_lassosum2)
 PSS011428|
South Asian Ancestry|
5,137 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0482 — —
PPM020836 PGS004651
(LDL_SAS_weighted_ldpred2)
 PSS011428|
South Asian Ancestry|
5,137 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0513 — —
PPM020837 PGS004652
(logTG_AFR_lassosum2)
 PSS011423|
African Ancestry|
4,300 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0367 — —
PPM020838 PGS004653
(logTG_AFR_ldpred2)
 PSS011423|
African Ancestry|
4,300 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.006 — —
PPM020839 PGS004654
(logTG_AFR_PROSPER)
 PSS011423|
African Ancestry|
4,300 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0528 — —
PPM020840 PGS004655
(logTG_AFR_weighted_lassosum2)
 PSS011423|
African Ancestry|
4,300 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0425 — —
PPM020841 PGS004656
(logTG_AFR_weighted_ldpred2)
 PSS011423|
African Ancestry|
4,300 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0198 — —
PPM020843 PGS004658
(logTG_EAS_ldpred2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0702 — —
PPM020844 PGS004659
(logTG_EAS_PROSPER)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.111 — —
PPM020845 PGS004660
(logTG_EAS_weighted_lassosum2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0973 — —
PPM020846 PGS004661
(logTG_EAS_weighted_ldpred2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0948 — —
PPM020847 PGS004662
(logTG_SAS_lassosum2)
 PSS011430|
South Asian Ancestry|
5,143 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0762 — —
PPM020848 PGS004663
(logTG_SAS_ldpred2)
 PSS011430|
South Asian Ancestry|
5,143 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0861 — —
PPM020850 PGS004665
(logTG_SAS_weighted_lassosum2)
 PSS011430|
South Asian Ancestry|
5,143 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.107 — —
PPM020851 PGS004666
(logTG_SAS_weighted_ldpred2)
 PSS011430|
South Asian Ancestry|
5,143 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.1172 — —
PPM020852 PGS004667
(TC_AFR_lassosum2)
 PSS011421|
African Ancestry|
4,302 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.1178 — —
PPM020853 PGS004668
(TC_AFR_ldpred2)
 PSS011421|
African Ancestry|
4,302 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.1045 — —
PPM020854 PGS004669
(TC_AFR_PROSPER)
 PSS011421|
African Ancestry|
4,302 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.132 — —
PPM020857 PGS004672
(TC_EAS_lassosum2)
 PSS011425|
East Asian Ancestry|
971 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.0758 — —
PPM020859 PGS004674
(TC_EAS_PROSPER)
 PSS011425|
East Asian Ancestry|
971 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.074 — —
PPM020860 PGS004675
(TC_EAS_weighted_lassosum2)
 PSS011425|
East Asian Ancestry|
971 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.1059 — —
PPM020861 PGS004676
(TC_EAS_weighted_ldpred2)
 PSS011425|
East Asian Ancestry|
971 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.1007 — —
PPM020862 PGS004677
(TC_SAS_lassosum2)
 PSS011429|
South Asian Ancestry|
5,153 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.0282 — —
PPM020863 PGS004678
(TC_SAS_ldpred2)
 PSS011429|
South Asian Ancestry|
5,153 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.0287 — —
PPM020864 PGS004679
(TC_SAS_PROSPER)
 PSS011429|
South Asian Ancestry|
5,153 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.0527 — —
PPM020866 PGS004681
(TC_SAS_weighted_ldpred2)
 PSS011429|
South Asian Ancestry|
5,153 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.0513 — —
PPM020867 PGS004682
(height_AFR_lassosum2)
 PSS011422|
African Ancestry|
4,527 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Height — — adjusted R2: 0.0079 — —
PPM020868 PGS004683
(height_AFR_ldpred2)
 PSS011422|
African Ancestry|
4,527 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Height — — adjusted R2: 0.0119 — —
PPM020869 PGS004684
(height_AFR_PROSPER)
 PSS011422|
African Ancestry|
4,527 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Height — — adjusted R2: 0.0479 — —
PPM020870 PGS004685
(height_AFR_weighted_lassosum2)
 PSS011422|
African Ancestry|
4,527 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Height — — adjusted R2: 0.0295 — —
PPM020871 PGS004686
(height_AFR_weighted_ldpred2)
 PSS011422|
African Ancestry|
4,527 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Height — — adjusted R2: 0.0297 — —
PPM020849 PGS004664
(logTG_SAS_PROSPER)
 PSS011430|
South Asian Ancestry|
5,143 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.1238 — —
PPM020855 PGS004670
(TC_AFR_weighted_lassosum2)
 PSS011421|
African Ancestry|
4,302 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.1232 — —
PPM020807 PGS004622
(HDL_AFR_lassosum2)
 PSS011419|
African Ancestry|
3,983 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.0872 — —
PPM020811 PGS004626
(HDL_AFR_weighted_ldpred2)
 PSS011419|
African Ancestry|
3,983 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.0974 — —
PPM020819 PGS004634
(HDL_SAS_PROSPER)
 PSS011427|
South Asian Ancestry|
4,702 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: HDL cholesterol — — adjusted R2: 0.1564 — —
PPM020826 PGS004641
(LDL_AFR_weighted_ldpred2)
 PSS011420|
African Ancestry|
4,292 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.1314 — —
PPM020834 PGS004649
(LDL_SAS_PROSPER)
 PSS011428|
South Asian Ancestry|
5,137 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: LDL cholesterol — — adjusted R2: 0.0561 — —
PPM020842 PGS004657
(logTG_EAS_lassosum2)
 PSS011426|
East Asian Ancestry|
970 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Log triglycerides — — adjusted R2: 0.0695 — —
PPM020858 PGS004673
(TC_EAS_ldpred2)
 PSS011425|
East Asian Ancestry|
971 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.077 — —
PPM020865 PGS004680
(TC_SAS_weighted_lassosum2)
 PSS011429|
South Asian Ancestry|
5,153 individuals
 PGP000595 |
Zhang J et al. Nat Commun (2024)
 Reported Trait: Total cholesterol — — adjusted R2: 0.0491 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011426 — — 970 individuals,
32.0 % Male samples
 Mean = 52.47 years
Sd = 7.81 years		 East Asian — UKB —
PSS011427 — — 4,702 individuals,
53.0 % Male samples
 Mean = 53.37 years
Sd = 8.43 years		 South Asian — UKB —
PSS011428 — — 5,137 individuals,
53.0 % Male samples
 Mean = 53.37 years
Sd = 8.43 years		 South Asian — UKB —
PSS011429 — — 5,153 individuals,
53.0 % Male samples
 Mean = 53.37 years
Sd = 8.43 years		 South Asian — UKB —
PSS011430 — — 5,143 individuals,
53.0 % Male samples
 Mean = 53.37 years
Sd = 8.43 years		 South Asian — UKB —
PSS011419 — — 3,983 individuals,
42.0 % Male samples
 Mean = 51.82 years
Sd = 8.06 years		 African American or Afro-Caribbean — UKB —
PSS011420 — — 4,292 individuals,
42.0 % Male samples
 Mean = 51.82 years
Sd = 8.06 years		 African American or Afro-Caribbean — UKB —
PSS011421 — — 4,302 individuals,
42.0 % Male samples
 Mean = 51.82 years
Sd = 8.06 years		 African American or Afro-Caribbean — UKB —
PSS011422 — — 4,527 individuals,
42.0 % Male samples
 Mean = 51.82 years
Sd = 8.06 years		 African American or Afro-Caribbean — UKB —
PSS011423 — — 4,300 individuals,
42.0 % Male samples
 Mean = 51.82 years
Sd = 8.06 years		 African American or Afro-Caribbean — UKB —
PSS011424 — — 892 individuals,
32.0 % Male samples
 Mean = 52.47 years
Sd = 7.81 years		 East Asian — UKB —
PSS011425 — — 971 individuals,
32.0 % Male samples
 Mean = 52.47 years
Sd = 7.81 years		 East Asian — UKB —