PGS Publication: PGP000726

Publication Information (EuropePMC)
Title The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening.
PubMed ID 34214236(Europe PMC)
doi 10.1111/bju.15535
Publication Date Aug. 15, 2021
Journal BJU Int
Author(s) Benafif S, Ni Raghallaigh H, McGrowder E, Saunders EJ, Brook MN, Saya S, Rageevakumar R, Wakerell S, James D, Chamberlain A, Taylor N, Hogben M, Benton B, D'Mello L, Myhill K, Mikropoulos C, Bowen-Perkins H, Rafi I, Ferris M, Beattie A, Kuganolipava S, Sevenoaks T, Bower J, Kumar P, Hazell S, deSouza NM, Antoniou A, Bancroft E, Kote-Jarai Z, Eeles R.
Released in PGS Catalog: May 20, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005205
(PRS130_Pca)
 PGP000726 |
Benafif S et al. BJU Int (2021)
 Prostate cancer prostate carcinoma 130
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005205/ScoringFiles/PGS005205.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022572 PGS005205
(PRS130_Pca)
 PSS012021|
European Ancestry|
297 individuals
 PGP000726 |
Benafif S et al. BJU Int (2021)
 Reported Trait: prostate cancer — — Percentage of screened individuals diagnosed with cancer: 38.9 % — Threshold (90th centile) = 11.15

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012021 — — 297 individuals,
100.0 % Male samples
 — European — BARCODE1 —