PGS Publication: PGP000858

Publication Information (EuropePMC)
Title Agent orange exposure and prostate cancer risk in the million veteran program.
PubMed ID 38779869(Europe PMC)
doi 10.2340/1651-226x.2024.25053
Publication Date May 23, 2024
Journal Acta Oncol
Author(s) Pagadala MS, Lui AJ, Zhong AY, Lynch JA, Karunamuni R, Lee KM, Plym A, Rose BS, Carter HK, Kibel AS, DuVall SL, Gaziano JM, Panizzon MS, Hauger RL, Seibert TM.
Released in PGS Catalog: Oct. 23, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003331
(PHS290)
 PGP000397 |
Huynh-Le MP et al. Prostate Cancer Prostatic Dis (2022)
 Prostate cancer prostate carcinoma 290
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003331/ScoringFiles/PGS003331.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038278 PGS003331
(PHS290)
 PSS013902|
Multi-ancestry (including European)|
301,470 individuals
 PGP000858 |
Pagadala MS et al. Acta Oncol (2024)
|Ext.		 Reported Trait: Fatal prostate cancer — — Hazard ratio (HR, high vs low tertile): 4.88 [3.83, 6.17] race/ethnicity, family history —
PPM038279 PGS003331
(PHS290)
 PSS013902|
Multi-ancestry (including European)|
301,470 individuals
 PGP000858 |
Pagadala MS et al. Acta Oncol (2024)
|Ext.		 Reported Trait: Metastatic prostate cancer — — Hazard ratio (HR, high vs low tertile): 4.42 [3.97, 4.94] race/ethnicity, family history —
PPM038280 PGS003331
(PHS290)
 PSS013902|
Multi-ancestry (including European)|
301,470 individuals
 PGP000858 |
Pagadala MS et al. Acta Oncol (2024)
|Ext.		 Reported Trait: Prostate cancer — — Hazard ratio (HR, high vs low tertile): 4.91 [4.74, 5.07] race/ethnicity, family history —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013902 — — 241,515 individuals,
100.0 % Male samples
 — European — MVP —
PSS013902 — — 45,257 individuals,
100.0 % Male samples
 — African American or Afro-Caribbean — MVP —
PSS013902 — — 1,915 individuals,
100.0 % Male samples
 — Asian unspecified — MVP —
PSS013902 — — 3,082 individuals,
100.0 % Male samples
 — Native American — MVP —
PSS013902 — — 1,292 individuals,
100.0 % Male samples
 — Oceanian
(Pacific Islander)		 — MVP —
PSS013902 — — 8,409 individuals,
100.0 % Male samples
 — Not reported — MVP —