Polygenic Score (PGS) ID: PGS002584

Predicted Trait
Reported Trait Cardiovascular disease
Mapped Trait(s) cardiovascular disorder (MONDO_0004995)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name disease_CARDIOVASCULAR.P+T.5e-08
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 5e-08
Variants
Original Genome Build GRCh37
Number of Variants 637
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
337,488 individuals (100%)
PGS Evaluation
European: 50%
African: 16.7%
East Asian: 16.7%
South Asian: 16.7%
6 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 337,488 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014202 PSS009708|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Cardiovascular disease — — Incremental R2 (full model vs. covariates alone): 0.0028 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014300 PSS009710|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Cardiovascular disease — — Incremental R2 (full model vs. covariates alone): 0.0042 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014153 PSS009707|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Cardiovascular disease — — Incremental R2 (full model vs. covariates alone): 0.005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014251 PSS009709|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Cardiovascular disease — — Incremental R2 (full model vs. covariates alone): 0.0101 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM038247 PSS013888|
European Ancestry|
924 individuals
 PGP000855 |
Dimitriou M et al. J Pers Med (2024)
|Ext.		 Reported Trait: Overall coronary artery disease OR: 1.483 — R²: 0.225 — —
PPM039259 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.0086 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009708 — — 922 individuals — East Asian — UKB —
PSS009709 — — 43,505 individuals — European Non-British European UKB —
PSS009710 — — 8,098 individuals — South Asian — UKB —
PSS013888 — —
[
  • 390 cases
  • , 534 controls
]
,
63.9 % Male samples
 Mean = 57.7 years
Sd = 12.4 years		 European
(Greek)		 — THISEAS —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —
PSS009707 — — 6,503 individuals — African unspecified — UKB —