PGS Catalog - Dimitriou M, J Pers Med (2024) (Publication)

PGS Publication: PGP000855

Publication Information (EuropePMC)
Title	Evaluation of Polygenic Risk Scores for Prediction of Coronary Artery Disease in a Greek Case-Control Study.
PubMed ID	38929788(Europe PMC)
doi	10.3390/jpm14060565
Publication Date	May 26, 2024
Journal	*J Pers Med*
Author(s)	Dimitriou M, Moulos P, Kalafati IP, Saranti G, Rallidis LS, Dedoussis GV.

Released in PGS Catalog: Oct. 23, 2026

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS002437 (disease_CARDIOVASCULAR.P+T.0.001)	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Cardiovascular disease	cardiovascular disorder	20,431	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002437/ScoringFiles/PGS002437.txt.gz
PGS002535 (disease_CARDIOVASCULAR.P+T.1e-06)	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Cardiovascular disease	cardiovascular disorder	1,218	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002535/ScoringFiles/PGS002535.txt.gz
PGS002633 (disease_CARDIOVASCULAR.PolyFun-pred)	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Cardiovascular disease	cardiovascular disorder	381,036	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002633/ScoringFiles/PGS002633.txt.gz
PGS000747 (PRS_EB)	PGP000152 \| Gola D et al. Circ Genom Precis Med (2020)	Coronary artery disease	coronary artery disorder	375,822		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000747/ScoringFiles/PGS000747.txt.gz
PGS000012 (GRS49K)	PGP000005 \| Abraham G et al. Eur Heart J (2016)	Coronary artery disease	coronary artery disorder	49,310		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz
PGS000337 (MetaPRS_CAD)	PGP000104 \| Koyama S et al. Nat Genet (2020)	Coronary artery disease	coronary artery disorder	75,028	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000337/ScoringFiles/PGS000337.txt.gz - Check Terms/Licenses
PGS000116 (CAD_EJ2020)	PGP000054 \| Elliott J et al. JAMA (2020)	Coronary artery disease	coronary artery disorder	40,079		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000116/ScoringFiles/PGS000116.txt.gz - Check Terms/Licenses
PGS002486 (disease_CARDIOVASCULAR.P+T.0.01)	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Cardiovascular disease	cardiovascular disorder	110,640	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002486/ScoringFiles/PGS002486.txt.gz
PGS002584 (disease_CARDIOVASCULAR.P+T.5e-08)	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Cardiovascular disease	cardiovascular disorder	637	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002584/ScoringFiles/PGS002584.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM038245	PGS002486 (disease_CARDIOVASCULAR.P+T.0.01)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.004	—	R²: 0.222	—	—
PPM038246	PGS002535 (disease_CARDIOVASCULAR.P+T.1e-06)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.442	—	R²: 0.227	—	—
PPM038247	PGS002584 (disease_CARDIOVASCULAR.P+T.5e-08)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.483	—	R²: 0.225	—	—
PPM038248	PGS002633 (disease_CARDIOVASCULAR.PolyFun-pred)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 4.084	—	R²: 0.229	—	—
PPM038249	PGS000012 (GRS49K)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.153	—	R²: 0.414	HellenicSCORE	—
PPM038250	PGS000116 (CAD_EJ2020)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 0.063	—	R²: 0.245	—	—
PPM038251	PGS000337 (MetaPRS_CAD)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.095	—	R²: 0.252	—	—
PPM038252	PGS000747 (PRS_EB)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.095	—	R²: 0.608	HellenicSCORE	—
PPM038244	PGS002437 (disease_CARDIOVASCULAR.P+T.0.001)	PSS013888\| European Ancestry\| 924 individuals	PGP000855 \| Dimitriou M et al. J Pers Med (2024) \|Ext.	Reported Trait: Overall coronary artery disease	OR: 1.016	—	R²: 0.222	—	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS013888	—	—	924 individuals [ 390 cases , 534 controls ] , 63.9 % Male samples	Mean = 57.7 years Sd = 12.4 years	European (Greek)	—	THISEAS	—