| Predicted Trait | |
| Reported Trait | Systolic blood pressure |
| Mapped Trait(s) | systolic blood pressure (EFO_0006335) |
| Score Construction | |
| PGS Name | SBP |
| Development Method | |
| Name | PRS-CS |
| Parameters | Global shrinkage parameter = 0.001 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,022,624 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000772 |
| Citation (link to publication) | Øvretveit K et al. Eur J Prev Cardiol (2024) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST006624 Europe PMC: 30224653 |
757,601 individuals | European | NR |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 81,117 individuals | European (Icelandic) |
deCODE | BP measurements and information about hypertension diagnoses were obtained from Landspitali-The National University Hospital of Iceland in Reykjavik, and the Primary Health Care Clinics of the Capital area, as well as at recruitment for deCODE studies, yielding BP measurements for 145 615 individuals with an average of 12 measurements per individual. A subset of 81 117 individuals with genotype information was used to calculate the PRSs | — | — | — | — |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM023196 | PSS012145| European Ancestry| 53,148 individuals |
PGP000772 | Øvretveit K et al. Eur J Prev Cardiol (2024) |
Reported Trait: Systolic Blood Pressure | β: 4.7 [4.5, 4.9] | — | — | — | Increase in mmHg per PGS SD + 95% CI |
| PPM023190 | PSS012143| European Ancestry| 57,933 individuals |
PGP000772 | Øvretveit K et al. Eur J Prev Cardiol (2024) |
Reported Trait: Systolic Blood Pressure | β: 5.1 [5.0, 5.3] | — | — | — | Increase in mmHg per PGS SD + 95% CI |
| PPM023187 | PSS012142| European Ancestry| 45,036 individuals |
PGP000772 | Øvretveit K et al. Eur J Prev Cardiol (2024) |
Reported Trait: Systolic Blood Pressure | β: 4.7 [4.5, 4.9] | — | — | — | Increase in mmHg per PGS SD + 95% CI |
| PPM023193 | PSS012144| European Ancestry| 49,228 individuals |
PGP000772 | Øvretveit K et al. Eur J Prev Cardiol (2024) |
Reported Trait: Systolic Blood Pressure | β: 4.7 [4.6, 4.9] | — | — | — | Increase in mmHg per PGS SD + 95% CI |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012144 | Participants were measured three times with an automated oscillometric device [Critikon Dinamap 845XT and 8100 (GE Medical Systems Information Technologies, Inc.) by the stationary team and XL9301 (Johnson & Johnson Medical, Inc.) by the mobile team in HUNT2-3 | — | 49,228 individuals, 45.0 % Male samples |
Mean = 53.2 years Sd = 16.0 years |
European (Norwegian) |
— | HUNT | — |
| PSS012145 | Participants were measured three times with an automated oscillometric device: Dinamap Carescape V100 (GE Medical Systems Information Technologies, Inc.) by all teams in HUNT4 | — | 53,148 individuals, 45.0 % Male samples |
Mean = 55.4 years Sd = 17.7 years |
European (Norwegian) |
— | HUNT | — |
| PSS012142 | BP was assessed twice with a calibrated mercury sphygmomanometer after a period of seated rest. SBP was recorded at the first Korotkoff sound | — | 45,036 individuals, 47.0 % Male samples |
Mean = 43.0 years Sd = 14.1 years |
European (Norwegian) |
— | HUNT | — |
| PSS012143 | Participants were measured three times with an automated oscillometric device [Critikon Dinamap 845XT and 8100 (GE Medical Systems Information Technologies, Inc.) by the stationary team and XL9301 (Johnson & Johnson Medical, Inc.) by the mobile team in HUNT2-3 | — | 57,933 individuals, 47.0 % Male samples |
Mean = 49.5 years Sd = 16.8 years |
European (Norwegian) |
— | HUNT | — |