PGS Publication: PGP000772

Publication Information (EuropePMC)
Title Polygenic risk scores associate with blood pressure traits across the lifespan.
PubMed ID 38007706(Europe PMC)
doi 10.1093/eurjpc/zwad365
Publication Date April 1, 2024
Journal Eur J Prev Cardiol
Author(s) Øvretveit K, Ingeström EML, Spitieris M, Tragante V, Wade KH, Thomas LF, Wolford BN, Wisløff U, Gudbjartsson DF, Holm H, Stefansson K, Brumpton BM, Hveem K.
Released in PGS Catalog: Dec. 18, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005351
(DBP)
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Diastolic blood pressure diastolic blood pressure 1,024,311
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005351/ScoringFiles/PGS005351.txt.gz
PGS005352
(PP)
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Pulse Pressure pulse pressure measurement 1,022,643
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005352/ScoringFiles/PGS005352.txt.gz
PGS005350
(SBP)
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Systolic blood pressure systolic blood pressure 1,022,624
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005350/ScoringFiles/PGS005350.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023196 PGS005350
(SBP)
 PSS012145|
European Ancestry|
53,148 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Systolic Blood Pressure β: 4.7 [4.5, 4.9] — — — Increase in mmHg per PGS SD + 95% CI
PPM023197 PGS005351
(DBP)
 PSS012145|
European Ancestry|
53,148 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Diastolic Blood Pressure β: 3.0 [2.9, 3.1] — — — Increase in mmHg per PGS SD + 95% CI
PPM023188 PGS005351
(DBP)
 PSS012142|
European Ancestry|
45,036 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Diastolic Blood Pressure β: 3.0 [2.8, 3.1] — — — Increase in mmHg per PGS SD + 95% CI
PPM023189 PGS005352
(PP)
 PSS012142|
European Ancestry|
45,036 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Pulse Pressure β: 2.8 [2.7, 2.9] — — — Increase in mmHg per PGS SD + 95% CI
PPM023190 PGS005350
(SBP)
 PSS012143|
European Ancestry|
57,933 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Systolic Blood Pressure β: 5.1 [5.0, 5.3] — — — Increase in mmHg per PGS SD + 95% CI
PPM023191 PGS005351
(DBP)
 PSS012143|
European Ancestry|
57,933 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Diastolic Blood Pressure β: 3.3 [3.2, 3.4] — — — Increase in mmHg per PGS SD + 95% CI
PPM023192 PGS005352
(PP)
 PSS012143|
European Ancestry|
57,933 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Pulse Pressure β: 3.0 [2.9, 3.1] — — — Increase in mmHg per PGS SD + 95% CI
PPM023194 PGS005351
(DBP)
 PSS012144|
European Ancestry|
49,228 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Diastolic Blood Pressure β: 3.1 [3.0, 3.2] — — — Increase in mmHg per PGS SD + 95% CI
PPM023195 PGS005352
(PP)
 PSS012144|
European Ancestry|
49,228 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Pulse Pressure β: 3.1 [3.0, 3.3] — — — Increase in mmHg per PGS SD + 95% CI
PPM023187 PGS005350
(SBP)
 PSS012142|
European Ancestry|
45,036 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Systolic Blood Pressure β: 4.7 [4.5, 4.9] — — — Increase in mmHg per PGS SD + 95% CI
PPM023193 PGS005350
(SBP)
 PSS012144|
European Ancestry|
49,228 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Systolic Blood Pressure β: 4.7 [4.6, 4.9] — — — Increase in mmHg per PGS SD + 95% CI
PPM023198 PGS005352
(PP)
 PSS012145|
European Ancestry|
53,148 individuals
 PGP000772 |
Øvretveit K et al. Eur J Prev Cardiol (2024)
 Reported Trait: Pulse Pressure β: 3.0 [2.9, 3.1] — — — Increase in mmHg per PGS SD + 95% CI

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012144 Participants were measured three times with an automated oscillometric device [Critikon Dinamap 845XT and 8100 (GE Medical Systems Information Technologies, Inc.) by the stationary team and XL9301 (Johnson & Johnson Medical, Inc.) by the mobile team in HUNT2-3 — 49,228 individuals,
45.0 % Male samples
 Mean = 53.2 years
Sd = 16.0 years		 European
(Norwegian)		 — HUNT —
PSS012145 Participants were measured three times with an automated oscillometric device: Dinamap Carescape V100 (GE Medical Systems Information Technologies, Inc.) by all teams in HUNT4 — 53,148 individuals,
45.0 % Male samples
 Mean = 55.4 years
Sd = 17.7 years		 European
(Norwegian)		 — HUNT —
PSS012142 BP was assessed twice with a calibrated mercury sphygmomanometer after a period of seated rest. SBP was recorded at the first Korotkoff sound — 45,036 individuals,
47.0 % Male samples
 Mean = 43.0 years
Sd = 14.1 years		 European
(Norwegian)		 — HUNT —
PSS012143 Participants were measured three times with an automated oscillometric device [Critikon Dinamap 845XT and 8100 (GE Medical Systems Information Technologies, Inc.) by the stationary team and XL9301 (Johnson & Johnson Medical, Inc.) by the mobile team in HUNT2-3 — 57,933 individuals,
47.0 % Male samples
 Mean = 49.5 years
Sd = 16.8 years		 European
(Norwegian)		 — HUNT —