| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0004312 |
| Description | The volume of air that is exhaled by a maximal expiration following a maximal inspiration. | Trait category |
Other measurement
|
| Synonyms |
2 synonyms
|
| Mapped terms |
4 mapped terms
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS001237 (GBE_INI3062) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Lung function (FVC) | vital capacity | 20,921 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001237/ScoringFiles/PGS001237.txt.gz |
| PGS001922 (portability-PLR_FVC) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Forced vital capacity (FVC), Best measure | vital capacity | 85,349 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001922/ScoringFiles/PGS001922.txt.gz |
| PGS002138 (portability-ldpred2_FVC) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Forced vital capacity (FVC), Best measure | vital capacity | 940,300 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002138/ScoringFiles/PGS002138.txt.gz |
| PGS002327 (lung_FVCzSMOKE.BOLT-LMM) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 1,109,311 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002327/ScoringFiles/PGS002327.txt.gz |
| PGS002399 (lung_FVCzSMOKE.P+T.0.0001) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 9,469 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002399/ScoringFiles/PGS002399.txt.gz |
| PGS002448 (lung_FVCzSMOKE.P+T.0.001) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 29,603 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002448/ScoringFiles/PGS002448.txt.gz |
| PGS002497 (lung_FVCzSMOKE.P+T.0.01) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 134,519 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002497/ScoringFiles/PGS002497.txt.gz |
| PGS002546 (lung_FVCzSMOKE.P+T.1e-06) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 2,327 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002546/ScoringFiles/PGS002546.txt.gz |
| PGS002595 (lung_FVCzSMOKE.P+T.5e-08) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 1,235 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002595/ScoringFiles/PGS002595.txt.gz |
| PGS002644 (lung_FVCzSMOKE.PolyFun-pred) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 592,696 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002644/ScoringFiles/PGS002644.txt.gz |
| PGS002693 (lung_FVCzSMOKE.SBayesR) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Forced vital capacity | vital capacity | 986,815 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002693/ScoringFiles/PGS002693.txt.gz |
| PGS004432 (X3062.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Forced vital capacity (FVC) | vital capacity | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004432/ScoringFiles/PGS004432.txt.gz |
| PGS004436 (X20151.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Forced vital capacity (FVC), Best measure | vital capacity | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004436/ScoringFiles/PGS004436.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM008694 | PGS001237 (GBE_INI3062) |
PSS007081| African Ancestry| 5,865 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: FVC | — | — | R²: 0.38605 [0.3675, 0.40459] Incremental R2 (full-covars): -0.00854 PGS R2 (no covariates): 0.00449 [0.00125, 0.00774] |
age, sex, UKB array type, Genotype PCs | — |
| PPM008695 | PGS001237 (GBE_INI3062) |
PSS007082| East Asian Ancestry| 1,590 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: FVC | — | — | R²: 0.48915 [0.45529, 0.52301] Incremental R2 (full-covars): 0.0239 PGS R2 (no covariates): 0.03634 [0.01893, 0.05375] |
age, sex, UKB array type, Genotype PCs | — |
| PPM008696 | PGS001237 (GBE_INI3062) |
PSS007083| European Ancestry| 22,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: FVC | — | — | R²: 0.53532 [0.52687, 0.54376] Incremental R2 (full-covars): 0.04669 PGS R2 (no covariates): 0.04902 [0.04379, 0.05425] |
age, sex, UKB array type, Genotype PCs | — |
| PPM008697 | PGS001237 (GBE_INI3062) |
PSS007084| South Asian Ancestry| 7,147 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: FVC | — | — | R²: 0.42603 [0.40944, 0.44262] Incremental R2 (full-covars): 0.00884 PGS R2 (no covariates): 0.02153 [0.01517, 0.02789] |
age, sex, UKB array type, Genotype PCs | — |
| PPM008698 | PGS001237 (GBE_INI3062) |
PSS007085| European Ancestry| 62,090 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: FVC | — | — | R²: 0.51644 [0.5112, 0.52169] Incremental R2 (full-covars): 0.04662 PGS R2 (no covariates): 0.04936 [0.04617, 0.05255] |
age, sex, UKB array type, Genotype PCs | — |
| PPM038496 | PGS001237 (GBE_INI3062) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.03139 | — | — | — | — |
| PPM010255 | PGS001922 (portability-PLR_FVC) |
PSS009370| European Ancestry| 15,118 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.3635 [0.3496, 0.3773] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010257 | PGS001922 (portability-PLR_FVC) |
PSS008698| European Ancestry| 4,520 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.3258 [0.2995, 0.3517] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010258 | PGS001922 (portability-PLR_FVC) |
PSS008472| Greater Middle Eastern Ancestry| 163 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.307 [0.1505, 0.4486] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010256 | PGS001922 (portability-PLR_FVC) |
PSS009144| European Ancestry| 2,907 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.346 [0.3135, 0.3777] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM038508 | PGS001922 (portability-PLR_FVC) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.03069 | — | — | — | — |
| PPM011955 | PGS002138 (portability-ldpred2_FVC) |
PSS009370| European Ancestry| 15,118 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.3604 [0.3464, 0.3742] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011956 | PGS002138 (portability-ldpred2_FVC) |
PSS009144| European Ancestry| 2,907 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.3369 [0.3042, 0.3689] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011957 | PGS002138 (portability-ldpred2_FVC) |
PSS008698| European Ancestry| 4,520 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.3329 [0.3066, 0.3586] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011958 | PGS002138 (portability-ldpred2_FVC) |
PSS008472| Greater Middle Eastern Ancestry| 163 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | Partial Correlation (partial-r): 0.3085 [0.1521, 0.4499] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM038511 | PGS002138 (portability-ldpred2_FVC) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.03069 | — | — | — | — |
| PPM013190 | PGS002327 (lung_FVCzSMOKE.BOLT-LMM) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.1004 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013092 | PGS002327 (lung_FVCzSMOKE.BOLT-LMM) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0293 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013141 | PGS002327 (lung_FVCzSMOKE.BOLT-LMM) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0397 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013239 | PGS002327 (lung_FVCzSMOKE.BOLT-LMM) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0676 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038566 | PGS002327 (lung_FVCzSMOKE.BOLT-LMM) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.02667 | — | — | — | — |
| PPM013380 | PGS002399 (lung_FVCzSMOKE.P+T.0.0001) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0007 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013429 | PGS002399 (lung_FVCzSMOKE.P+T.0.0001) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0043 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013478 | PGS002399 (lung_FVCzSMOKE.P+T.0.0001) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0424 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013527 | PGS002399 (lung_FVCzSMOKE.P+T.0.0001) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0256 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038833 | PGS002399 (lung_FVCzSMOKE.P+T.0.0001) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.01758 | — | — | — | — |
| PPM013576 | PGS002448 (lung_FVCzSMOKE.P+T.0.001) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0006 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013674 | PGS002448 (lung_FVCzSMOKE.P+T.0.001) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0381 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013723 | PGS002448 (lung_FVCzSMOKE.P+T.0.001) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0045 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013625 | PGS002448 (lung_FVCzSMOKE.P+T.0.001) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0052 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038696 | PGS002448 (lung_FVCzSMOKE.P+T.0.001) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.05113 | — | — | — | — |
| PPM013772 | PGS002497 (lung_FVCzSMOKE.P+T.0.01) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013821 | PGS002497 (lung_FVCzSMOKE.P+T.0.01) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0001 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013919 | PGS002497 (lung_FVCzSMOKE.P+T.0.01) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0025 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013870 | PGS002497 (lung_FVCzSMOKE.P+T.0.01) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0295 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038489 | PGS002497 (lung_FVCzSMOKE.P+T.0.01) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.09838 | — | — | — | — |
| PPM013968 | PGS002546 (lung_FVCzSMOKE.P+T.1e-06) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.006 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014017 | PGS002546 (lung_FVCzSMOKE.P+T.1e-06) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0154 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014066 | PGS002546 (lung_FVCzSMOKE.P+T.1e-06) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0241 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014115 | PGS002546 (lung_FVCzSMOKE.P+T.1e-06) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0168 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM039104 | PGS002546 (lung_FVCzSMOKE.P+T.1e-06) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.01046 | — | — | — | — |
| PPM014164 | PGS002595 (lung_FVCzSMOKE.P+T.5e-08) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0051 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014213 | PGS002595 (lung_FVCzSMOKE.P+T.5e-08) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0052 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014262 | PGS002595 (lung_FVCzSMOKE.P+T.5e-08) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0168 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014311 | PGS002595 (lung_FVCzSMOKE.P+T.5e-08) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0107 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM039150 | PGS002595 (lung_FVCzSMOKE.P+T.5e-08) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.00977 | — | — | — | — |
| PPM014360 | PGS002644 (lung_FVCzSMOKE.PolyFun-pred) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0296 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014409 | PGS002644 (lung_FVCzSMOKE.PolyFun-pred) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0531 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014458 | PGS002644 (lung_FVCzSMOKE.PolyFun-pred) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1044 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014507 | PGS002644 (lung_FVCzSMOKE.PolyFun-pred) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0707 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See lung_FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM038911 | PGS002644 (lung_FVCzSMOKE.PolyFun-pred) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.01414 | — | — | — | — |
| PPM014556 | PGS002693 (lung_FVCzSMOKE.SBayesR) |
PSS009751| African Ancestry| 4,243 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0276 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014605 | PGS002693 (lung_FVCzSMOKE.SBayesR) |
PSS009752| East Asian Ancestry| 679 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0474 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014654 | PGS002693 (lung_FVCzSMOKE.SBayesR) |
PSS009753| European Ancestry| 34,753 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0952 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014703 | PGS002693 (lung_FVCzSMOKE.SBayesR) |
PSS009754| South Asian Ancestry| 5,538 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Forced Vital Capacity | — | — | Incremental R2 (full model vs. covariates alone): 0.0658 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038569 | PGS002693 (lung_FVCzSMOKE.SBayesR) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.02677 | — | — | — | — |
| PPM020547 | PGS004432 (X3062.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Forced vital capacity (FVC) | — | — | PGS R2 (no covariates): 0.19162 | — | — |
| PPM020551 | PGS004436 (X20151.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Forced vital capacity (FVC), Best measure | — | — | PGS R2 (no covariates): 0.19024 | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009751 | — | — | 4,243 individuals | — | African unspecified | — | UKB | — |
| PSS009752 | — | — | 679 individuals | — | East Asian | — | UKB | — |
| PSS007081 | — | — | 5,865 individuals | — | African unspecified | — | UKB | — |
| PSS007082 | — | — | 1,590 individuals | — | East Asian | — | UKB | — |
| PSS007083 | — | — | 22,831 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007084 | — | — | 7,147 individuals | — | South Asian | — | UKB | — |
| PSS007085 | — | — | 62,090 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009753 | — | — | 34,753 individuals | — | European | Non-British European | UKB | — |
| PSS009754 | — | — | 5,538 individuals | — | South Asian | — | UKB | — |
| PSS008472 | — | — | 163 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS009144 | — | — | 2,907 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS009370 | — | — | 15,118 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS008698 | — | — | 4,520 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS013916 | — | — | [ ,
46.21 % Male samples |
— | European (British, Irish) |
— | UKB | — |