Trait: total blood protein measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004536
Description A total blood protein measurement is a quantification of protein in a blood sample. It is used as a marker for disease and nutrition. It is performed in the liquid portion of blood and typically measures albumin and globulin.
Trait category
Hematological measurement
Synonyms 2 synonyms
  • TBP
  • serum total protein

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000698
(snpnet.Total_protein)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Total protein [g/L] total blood protein measurement 16,420
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000698/ScoringFiles/PGS000698.txt.gz - Check Terms/Licenses
PGS002001
(portability-PLR_protein)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Total protein total blood protein measurement 69,557
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002001/ScoringFiles/PGS002001.txt.gz
PGS002219
(portability-ldpred2_protein)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Total protein total blood protein measurement 819,013
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002219/ScoringFiles/PGS002219.txt.gz
PGS004341
(X30860.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Total protein (g/L) total blood protein measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004341/ScoringFiles/PGS004341.txt.gz
PGS004849
(Total_protein_PRSmix_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Total protein measurement total blood protein measurement 2,167,123
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004849/ScoringFiles/PGS004849.txt.gz
PGS004850
(Total_protein_PRSmixPlus_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Total protein measurement total blood protein measurement 937,777
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004850/ScoringFiles/PGS004850.txt.gz
PGS004851
(TotalProtein_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Total protein measurement total blood protein measurement 593,738
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004851/ScoringFiles/PGS004851.txt.gz
PGS004852
(TotalProtein_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Total protein measurement total blood protein measurement 724,061
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004852/ScoringFiles/PGS004852.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001426 PGS000698
(snpnet.Total_protein)
 PSS000767|
African Ancestry|
5,573 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Total protein [g/L] — — R²: 0.04363
Spearman's ρ: 0.144		 Age, sex, PCs(1-40) —
PPM001531 PGS000698
(snpnet.Total_protein)
 PSS000770|
South Asian Ancestry|
6,687 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Total protein [g/L] — — R²: 0.10522
Spearman's ρ: 0.258		 Age, sex, PCs(1-40) —
PPM001566 PGS000698
(snpnet.Total_protein)
 PSS000771|
European Ancestry|
58,196 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Total protein [g/L] — — R²: 0.11218
Spearman's ρ: 0.284		 Age, sex, PCs(1-40) —
PPM001461 PGS000698
(snpnet.Total_protein)
 PSS000768|
East Asian Ancestry|
984 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Total protein [g/L] — — R²: 0.09275
Spearman's ρ: 0.247		 Age, sex, PCs(1-40) —
PPM001496 PGS000698
(snpnet.Total_protein)
 PSS000769|
European Ancestry|
21,516 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Total protein [g/L] — — R²: 0.11654
Spearman's ρ: 0.282		 Age, sex, PCs(1-40) —
PPM007415 PGS000698
(snpnet.Total_protein)
 PSS007201|
African Ancestry|
5,659 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Total protein — — R²: 0.01038 [0.00548, 0.01528]
Incremental R2 (full-covars): 0.00061
PGS R2 (no covariates): 0.02117 [0.01425, 0.0281]		 age, sex, UKB array type, Genotype PCs —
PPM007416 PGS000698
(snpnet.Total_protein)
 PSS007202|
East Asian Ancestry|
1,474 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Total protein — — R²: 0.04549 [0.0262, 0.06478]
Incremental R2 (full-covars): 0.00107
PGS R2 (no covariates): 0.05677 [0.03548, 0.07807]		 age, sex, UKB array type, Genotype PCs —
PPM007417 PGS000698
(snpnet.Total_protein)
 PSS007203|
European Ancestry|
21,730 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Total protein — — R²: 0.01493 [0.01194, 0.01792]
Incremental R2 (full-covars): 0.00167
PGS R2 (no covariates): 0.07937 [0.07293, 0.08581]		 age, sex, UKB array type, Genotype PCs —
PPM007418 PGS000698
(snpnet.Total_protein)
 PSS007204|
South Asian Ancestry|
6,788 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Total protein — — R²: 0.01363 [0.00853, 0.01873]
Incremental R2 (full-covars): 0.00134
PGS R2 (no covariates): 0.0679 [0.05715, 0.07866]		 age, sex, UKB array type, Genotype PCs —
PPM007419 PGS000698
(snpnet.Total_protein)
 PSS007205|
European Ancestry|
59,024 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Total protein — — R²: 0.00668 [0.00545, 0.0079]
Incremental R2 (full-covars): 0.00176
PGS R2 (no covariates): 0.08081 [0.07687, 0.08476]		 age, sex, UKB array type, Genotype PCs —
PPM010883 PGS002001
(portability-PLR_protein)
 PSS009485|
European Ancestry|
17,433 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.3216 [0.3082, 0.3348] sex, age, birth date, deprivation index, 16 PCs —
PPM010884 PGS002001
(portability-PLR_protein)
 PSS009259|
European Ancestry|
3,593 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.3209 [0.2911, 0.35] sex, age, birth date, deprivation index, 16 PCs —
PPM010885 PGS002001
(portability-PLR_protein)
 PSS008813|
European Ancestry|
5,794 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.3023 [0.2787, 0.3256] sex, age, birth date, deprivation index, 16 PCs —
PPM010886 PGS002001
(portability-PLR_protein)
 PSS008587|
Greater Middle Eastern Ancestry|
1,036 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.2629 [0.2047, 0.3192] sex, age, birth date, deprivation index, 16 PCs —
PPM010887 PGS002001
(portability-PLR_protein)
 PSS008365|
South Asian Ancestry|
5,483 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.2907 [0.2662, 0.3148] sex, age, birth date, deprivation index, 16 PCs —
PPM010888 PGS002001
(portability-PLR_protein)
 PSS008142|
East Asian Ancestry|
1,562 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.2431 [0.1955, 0.2895] sex, age, birth date, deprivation index, 16 PCs —
PPM010889 PGS002001
(portability-PLR_protein)
 PSS007929|
African Ancestry|
2,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.1497 [0.108, 0.1909] sex, age, birth date, deprivation index, 16 PCs —
PPM010890 PGS002001
(portability-PLR_protein)
 PSS009033|
African Ancestry|
3,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.1462 [0.113, 0.179] sex, age, birth date, deprivation index, 16 PCs —
PPM038955 PGS002001
(portability-PLR_protein)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.01309 — — — —
PPM012599 PGS002219
(portability-ldpred2_protein)
 PSS009485|
European Ancestry|
17,433 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.3191 [0.3057, 0.3324] sex, age, birth date, deprivation index, 16 PCs —
PPM012600 PGS002219
(portability-ldpred2_protein)
 PSS009259|
European Ancestry|
3,593 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.3196 [0.2899, 0.3488] sex, age, birth date, deprivation index, 16 PCs —
PPM012601 PGS002219
(portability-ldpred2_protein)
 PSS008813|
European Ancestry|
5,794 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.2989 [0.2752, 0.3222] sex, age, birth date, deprivation index, 16 PCs —
PPM012602 PGS002219
(portability-ldpred2_protein)
 PSS008587|
Greater Middle Eastern Ancestry|
1,036 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.243 [0.1842, 0.3] sex, age, birth date, deprivation index, 16 PCs —
PPM012603 PGS002219
(portability-ldpred2_protein)
 PSS008365|
South Asian Ancestry|
5,483 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.2818 [0.2572, 0.306] sex, age, birth date, deprivation index, 16 PCs —
PPM012604 PGS002219
(portability-ldpred2_protein)
 PSS008142|
East Asian Ancestry|
1,562 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.244 [0.1965, 0.2904] sex, age, birth date, deprivation index, 16 PCs —
PPM012606 PGS002219
(portability-ldpred2_protein)
 PSS009033|
African Ancestry|
3,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.138 [0.1048, 0.1709] sex, age, birth date, deprivation index, 16 PCs —
PPM012605 PGS002219
(portability-ldpred2_protein)
 PSS007929|
African Ancestry|
2,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total protein — — Partial Correlation (partial-r): 0.1313 [0.0894, 0.1727] sex, age, birth date, deprivation index, 16 PCs —
PPM039191 PGS002219
(portability-ldpred2_protein)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.00941 — — — —
PPM020456 PGS004341
(X30860.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Total protein (g/L) — — PGS R2 (no covariates): 0.21416 — —
PPM021074 PGS004849
(Total_protein_PRSmix_sas)
 PSS011476|
South Asian Ancestry|
6,486 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Total protein measurement — — Incremental R2 (Full model versus model with only covariates): 0.058 [0.047, 0.069] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM021075 PGS004850
(Total_protein_PRSmixPlus_sas)
 PSS011476|
South Asian Ancestry|
6,486 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Total protein measurement — — Incremental R2 (Full model versus model with only covariates): 0.059 [0.048, 0.07] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM021076 PGS004851
(TotalProtein_PRSmix_eur)
 PSS011475|
European Ancestry|
5,330 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Total protein measurement — — Incremental R2 (Full model versus model with only covariates): 0.04 [0.03, 0.051] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM021077 PGS004852
(TotalProtein_PRSmixPlus_eur)
 PSS011475|
European Ancestry|
5,330 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Total protein measurement — — Incremental R2 (Full model versus model with only covariates): 0.041 [0.03, 0.051] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009033 — — 3,404 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008142 — — 1,562 individuals — East Asian China (East Asia) UKB —
PSS011475 — — 5,330 individuals — European — AllofUs —
PSS011476 — — 6,486 individuals — South Asian — G&H —
PSS008813 — — 5,794 individuals — European Italy (South Europe) UKB —
PSS007929 — — 2,161 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008587 — — 1,036 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009485 — — 17,433 individuals — European UK (+ Ireland) UKB —
PSS000767 — — 5,573 individuals — African unspecified — UKB —
PSS000768 — — 984 individuals — East Asian — UKB —
PSS000769 — — 21,516 individuals — European Non-British White UKB —
PSS000770 — — 6,687 individuals — South Asian — UKB —
PSS000771 — — 58,196 individuals — European
(British)		 — UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS007201 — — 5,659 individuals — African unspecified — UKB —
PSS007202 — — 1,474 individuals — East Asian — UKB —
PSS007203 — — 21,730 individuals — European non-white British ancestry UKB —
PSS007204 — — 6,788 individuals — South Asian — UKB —
PSS007205 — — 59,024 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009259 — — 3,593 individuals — European Poland (NE Europe) UKB —
PSS008365 — — 5,483 individuals — South Asian India (South Asia) UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —