| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0009102 |
| Description | A measurement of the number of children born | Trait category |
Other measurement
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002309 (repro_NumberChildrenEverBorn_Pooled.BOLT-LMM) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 1,109,311 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002309/ScoringFiles/PGS002309.txt.gz |
| PGS002381 (repro_NumberChildrenEverBorn_Pooled.P+T.0.0001) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 1,639 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002381/ScoringFiles/PGS002381.txt.gz |
| PGS002430 (repro_NumberChildrenEverBorn_Pooled.P+T.0.001) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 11,512 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002430/ScoringFiles/PGS002430.txt.gz |
| PGS002479 (repro_NumberChildrenEverBorn_Pooled.P+T.0.01) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 89,453 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002479/ScoringFiles/PGS002479.txt.gz |
| PGS002528 (repro_NumberChildrenEverBorn_Pooled.P+T.1e-06) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 66 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002528/ScoringFiles/PGS002528.txt.gz |
| PGS002577 (repro_NumberChildrenEverBorn_Pooled.P+T.5e-08) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 21 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002577/ScoringFiles/PGS002577.txt.gz |
| PGS002626 (repro_NumberChildrenEverBorn_Pooled.PolyFun-pred) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 208,715 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002626/ScoringFiles/PGS002626.txt.gz |
| PGS002675 (repro_NumberChildrenEverBorn_Pooled.SBayesR) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Number of children ever born | number of children ever born measurement | 981,889 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002675/ScoringFiles/PGS002675.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM013123 | PGS002309 (repro_NumberChildrenEverBorn_Pooled.BOLT-LMM) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0011 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013172 | PGS002309 (repro_NumberChildrenEverBorn_Pooled.BOLT-LMM) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0082 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013221 | PGS002309 (repro_NumberChildrenEverBorn_Pooled.BOLT-LMM) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0032 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013074 | PGS002309 (repro_NumberChildrenEverBorn_Pooled.BOLT-LMM) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0005 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038433 | PGS002309 (repro_NumberChildrenEverBorn_Pooled.BOLT-LMM) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.04186 | — | — | — | — |
| PPM013362 | PGS002381 (repro_NumberChildrenEverBorn_Pooled.P+T.0.0001) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013411 | PGS002381 (repro_NumberChildrenEverBorn_Pooled.P+T.0.0001) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0013 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013460 | PGS002381 (repro_NumberChildrenEverBorn_Pooled.P+T.0.0001) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0003 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013509 | PGS002381 (repro_NumberChildrenEverBorn_Pooled.P+T.0.0001) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM039101 | PGS002381 (repro_NumberChildrenEverBorn_Pooled.P+T.0.0001) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.0396 | — | — | — | — |
| PPM013558 | PGS002430 (repro_NumberChildrenEverBorn_Pooled.P+T.0.001) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: #Children | — | — | Incremental R2 (full model vs. covariates alone): 0.0002 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013607 | PGS002430 (repro_NumberChildrenEverBorn_Pooled.P+T.0.001) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: #Children | — | — | Incremental R2 (full model vs. covariates alone): 0.0006 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013656 | PGS002430 (repro_NumberChildrenEverBorn_Pooled.P+T.0.001) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: #Children | — | — | Incremental R2 (full model vs. covariates alone): 0.0002 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013705 | PGS002430 (repro_NumberChildrenEverBorn_Pooled.P+T.0.001) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: #Children | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038703 | PGS002430 (repro_NumberChildrenEverBorn_Pooled.P+T.0.001) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.10886 | — | — | — | — |
| PPM013754 | PGS002479 (repro_NumberChildrenEverBorn_Pooled.P+T.0.01) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0009 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013852 | PGS002479 (repro_NumberChildrenEverBorn_Pooled.P+T.0.01) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0005 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013901 | PGS002479 (repro_NumberChildrenEverBorn_Pooled.P+T.0.01) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013803 | PGS002479 (repro_NumberChildrenEverBorn_Pooled.P+T.0.01) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0042 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038494 | PGS002479 (repro_NumberChildrenEverBorn_Pooled.P+T.0.01) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.18375 | — | — | — | — |
| PPM013950 | PGS002528 (repro_NumberChildrenEverBorn_Pooled.P+T.1e-06) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013999 | PGS002528 (repro_NumberChildrenEverBorn_Pooled.P+T.1e-06) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0047 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014048 | PGS002528 (repro_NumberChildrenEverBorn_Pooled.P+T.1e-06) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0002 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014097 | PGS002528 (repro_NumberChildrenEverBorn_Pooled.P+T.1e-06) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0004 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014146 | PGS002577 (repro_NumberChildrenEverBorn_Pooled.P+T.5e-08) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0006 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014195 | PGS002577 (repro_NumberChildrenEverBorn_Pooled.P+T.5e-08) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0023 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014244 | PGS002577 (repro_NumberChildrenEverBorn_Pooled.P+T.5e-08) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0003 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014293 | PGS002577 (repro_NumberChildrenEverBorn_Pooled.P+T.5e-08) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0004 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM039208 | PGS002577 (repro_NumberChildrenEverBorn_Pooled.P+T.5e-08) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.00932 | — | — | — | — |
| PPM014391 | PGS002626 (repro_NumberChildrenEverBorn_Pooled.PolyFun-pred) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0011 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014440 | PGS002626 (repro_NumberChildrenEverBorn_Pooled.PolyFun-pred) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0082 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014489 | PGS002626 (repro_NumberChildrenEverBorn_Pooled.PolyFun-pred) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.003 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM014342 | PGS002626 (repro_NumberChildrenEverBorn_Pooled.PolyFun-pred) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0005 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | See repro_NumberChildrenEverBorn_Pooled.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights |
| PPM038659 | PGS002626 (repro_NumberChildrenEverBorn_Pooled.PolyFun-pred) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.02329 | — | — | — | — |
| PPM014636 | PGS002675 (repro_NumberChildrenEverBorn_Pooled.SBayesR) |
PSS009681| European Ancestry| 43,069 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0075 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014538 | PGS002675 (repro_NumberChildrenEverBorn_Pooled.SBayesR) |
PSS009679| African Ancestry| 6,193 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0011 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014587 | PGS002675 (repro_NumberChildrenEverBorn_Pooled.SBayesR) |
PSS009680| East Asian Ancestry| 909 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0017 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM014685 | PGS002675 (repro_NumberChildrenEverBorn_Pooled.SBayesR) |
PSS009682| South Asian Ancestry| 7,846 individuals |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Reported Trait: Number of children ever born | — | — | Incremental R2 (full model vs. covariates alone): 0.0032 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM038422 | PGS002675 (repro_NumberChildrenEverBorn_Pooled.SBayesR) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.04463 | — | — | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009679 | — | — | 6,193 individuals | — | African unspecified | — | UKB | — |
| PSS009680 | — | — | 909 individuals | — | East Asian | — | UKB | — |
| PSS009681 | — | — | 43,069 individuals | — | European | Non-British European | UKB | — |
| PSS009682 | — | — | 7,846 individuals | — | South Asian | — | UKB | — |
| PSS013916 | — | — | [ ,
46.21 % Male samples |
— | European (British, Irish) |
— | UKB | — |