| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0010701 |
| Description | Mean volume of reticulocyte cells | Trait category |
Other measurement
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000180 (mrv) |
PGP000078 | Vuckovic D et al. Cell (2020) |
Mean reticulocyte volume | mean reticulocyte volume | 629 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000180/ScoringFiles/PGS000180.txt.gz |
| PGS000987 (GBE_INI30260) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Mean reticulocyte volume | mean reticulocyte volume | 13,277 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000987/ScoringFiles/PGS000987.txt.gz |
| PGS002003 (portability-PLR_reticulocyte_volume) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Mean reticulocyte volume | mean reticulocyte volume | 24,536 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002003/ScoringFiles/PGS002003.txt.gz |
| PGS002221 (portability-ldpred2_reticulocyte_volume) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Mean reticulocyte volume | mean reticulocyte volume | 523,074 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002221/ScoringFiles/PGS002221.txt.gz |
| PGS003567 (cont-decay-reticulocyte_volume) |
PGP000457 | Ding Y et al. Nature (2023) |
Mean reticulocyte volume | mean reticulocyte volume | 979,739 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003567/ScoringFiles/PGS003567.txt.gz |
| PGS003948 (INI30260) |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Mean reticulocyte volume | mean reticulocyte volume | 18,832 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003948/ScoringFiles/PGS003948.txt.gz |
| PGS004365 (X30260.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Mean reticulocyte volume | mean reticulocyte volume | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004365/ScoringFiles/PGS004365.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM038953 | PGS000180 (mrv) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.01349 | — | — | — | — |
| PPM007703 | PGS000987 (GBE_INI30260) |
PSS007026| African Ancestry| 5,973 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.03718 [0.02815, 0.0462] Incremental R2 (full-covars): 0.02777 PGS R2 (no covariates): 0.02867 [0.02068, 0.03667] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007704 | PGS000987 (GBE_INI30260) |
PSS007027| East Asian Ancestry| 1,623 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.08812 [0.06247, 0.11377] Incremental R2 (full-covars): 0.07173 PGS R2 (no covariates): 0.07447 [0.05053, 0.0984] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007705 | PGS000987 (GBE_INI30260) |
PSS007028| European Ancestry| 23,687 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.1616 [0.15323, 0.16997] Incremental R2 (full-covars): 0.14435 PGS R2 (no covariates): 0.1455 [0.1374, 0.15359] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007706 | PGS000987 (GBE_INI30260) |
PSS007029| South Asian Ancestry| 7,323 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.13294 [0.11894, 0.14694] Incremental R2 (full-covars): 0.09343 PGS R2 (no covariates): 0.09786 [0.08537, 0.11036] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007707 | PGS000987 (GBE_INI30260) |
PSS007030| European Ancestry| 64,570 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.15675 [0.15171, 0.16179] Incremental R2 (full-covars): 0.14554 PGS R2 (no covariates): 0.14631 [0.14138, 0.15124] |
age, sex, UKB array type, Genotype PCs | — |
| PPM038973 | PGS000987 (GBE_INI30260) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.01263 | — | — | — | — |
| PPM010898 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS009487| European Ancestry| 19,120 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3934 [0.3814, 0.4054] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010899 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS009261| European Ancestry| 3,924 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3882 [0.3612, 0.4145] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010900 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS008815| European Ancestry| 6,298 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3774 [0.356, 0.3984] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010901 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS008589| Greater Middle Eastern Ancestry| 1,127 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3348 [0.2815, 0.3861] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010902 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS008367| South Asian Ancestry| 5,935 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3217 [0.2986, 0.3443] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010903 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS008143| East Asian Ancestry| 1,722 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.2638 [0.219, 0.3074] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010904 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS007931| African Ancestry| 2,293 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.2125 [0.1729, 0.2514] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010905 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS009035| African Ancestry| 3,602 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.1616 [0.1296, 0.1934] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM038842 | PGS002003 (portability-PLR_reticulocyte_volume) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.0157 | — | — | — | — |
| PPM012614 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS009487| European Ancestry| 19,120 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3894 [0.3773, 0.4014] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012615 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS009261| European Ancestry| 3,924 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3877 [0.3608, 0.4141] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012616 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS008815| European Ancestry| 6,298 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3736 [0.3521, 0.3947] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012617 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS008589| Greater Middle Eastern Ancestry| 1,127 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3308 [0.2773, 0.3823] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012618 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS008367| South Asian Ancestry| 5,935 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.3152 [0.2921, 0.338] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012619 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS008143| East Asian Ancestry| 1,722 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.2541 [0.2091, 0.298] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012620 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS007931| African Ancestry| 2,293 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.2118 [0.1722, 0.2507] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012621 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS009035| African Ancestry| 3,602 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Mean reticulocyte volume | — | — | Partial Correlation (partial-r): 0.1834 [0.1516, 0.2149] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM038846 | PGS002221 (portability-ldpred2_reticulocyte_volume) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: -0.01553 | — | — | — | — |
| PPM017495 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010934| European Ancestry| 19,112 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.15 | sex, age, deprivation index, PC1-16 | — |
| PPM017579 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010850| European Ancestry| 3,913 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.15 | sex, age, deprivation index, PC1-16 | — |
| PPM017663 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010682| European Ancestry| 6,144 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.13 | sex, age, deprivation index, PC1-16 | — |
| PPM017747 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010598| Greater Middle Eastern Ancestry| 1,097 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.1 | sex, age, deprivation index, PC1-16 | — |
| PPM017831 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010262| European Ancestry| 2,221 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.16 | sex, age, deprivation index, PC1-16 | — |
| PPM017915 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010514| South Asian Ancestry| 5,886 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.1 | sex, age, deprivation index, PC1-16 | — |
| PPM017999 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010430| East Asian Ancestry| 1,711 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.06 | sex, age, deprivation index, PC1-16 | — |
| PPM018083 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010346| African Ancestry| 2,281 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.04 | sex, age, deprivation index, PC1-16 | — |
| PPM018167 | PGS003567 (cont-decay-reticulocyte_volume) |
PSS010766| African Ancestry| 3,574 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Mean reticulocyte volume | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM019059 | PGS003948 (INI30260) |
PSS011140| European Ancestry| 64,861 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.16087 [0.1558, 0.16594] PGS R2 (no covariates): 0.14603 [0.14111, 0.15095] Incremental R2 (full-covars): 0.14515 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM019060 | PGS003948 (INI30260) |
PSS011099| European Ancestry| 2,770 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.17217 [0.14717, 0.19717] PGS R2 (no covariates): 0.14414 [0.1205, 0.16779] Incremental R2 (full-covars): 0.14281 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM019061 | PGS003948 (INI30260) |
PSS011111| South Asian Ancestry| 1,393 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.13781 [0.10535, 0.17027] PGS R2 (no covariates): 0.11019 [0.08024, 0.14015] Incremental R2 (full-covars): 0.10391 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM019062 | PGS003948 (INI30260) |
PSS011152| African Ancestry| 1,124 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.03874 [0.01751, 0.05997] PGS R2 (no covariates): 0.03349 [0.01364, 0.05333] Incremental R2 (full-covars): 0.033 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM019063 | PGS003948 (INI30260) |
PSS011169| Multi-ancestry (excluding European)| 7,578 individuals |
PGP000502 | Tanigawa Y et al. AJHG (2023) |
Reported Trait: Mean reticulocyte volume | — | — | R²: 0.15509 [0.14052, 0.16966] PGS R2 (no covariates): 0.13046 [0.11671, 0.14422] Incremental R2 (full-covars): 0.11887 |
age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM020480 | PGS004365 (X30260.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Mean reticulocyte volume | — | — | PGS R2 (no covariates): 0.26343 | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011140 | — | — | 64,861 individuals | — | European (white British ancestry) |
— | UKB | — |
| PSS009035 | — | — | 3,602 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008143 | — | — | 1,722 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS011152 | — | — | 1,124 individuals | — | African unspecified | — | UKB | — |
| PSS010934 | — | — | 19,112 individuals, 46.0 % Male samples |
Mean = 56.9 years Sd = 7.9 years |
European | white British | UKB | — |
| PSS010682 | — | — | 6,144 individuals, 45.0 % Male samples |
Mean = 54.4 years Sd = 8.4 years |
European | Italian | UKB | — |
| PSS011169 | — | — | 7,578 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |
| PSS010430 | — | — | 1,711 individuals, 33.0 % Male samples |
Mean = 52.4 years Sd = 7.8 years |
East Asian | Chinese | UKB | — |
| PSS008815 | — | — | 6,298 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS007026 | — | — | 5,973 individuals | — | African unspecified | — | UKB | — |
| PSS007931 | — | — | 2,293 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS007027 | — | — | 1,623 individuals | — | East Asian | — | UKB | — |
| PSS007028 | — | — | 23,687 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007029 | — | — | 7,323 individuals | — | South Asian | — | UKB | — |
| PSS007030 | — | — | 64,570 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS010850 | — | — | 3,913 individuals, 38.0 % Male samples |
Mean = 54.3 years Sd = 7.5 years |
European | Polish | UKB | — |
| PSS010598 | — | — | 1,097 individuals, 59.0 % Male samples |
Mean = 52.0 years Sd = 8.0 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
| PSS008589 | — | — | 1,127 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS009487 | — | — | 19,120 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS010346 | — | — | 2,281 individuals, 37.0 % Male samples |
Mean = 52.4 years Sd = 8.0 years |
African American or Afro-Caribbean | Caribbean | UKB | — |
| PSS011099 | — | — | 2,770 individuals | — | European (non-white British ancestry) |
— | UKB | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS011111 | — | — | 1,393 individuals | — | South Asian | — | UKB | — |
| PSS009261 | — | — | 3,924 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS008367 | — | — | 5,935 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS010766 | — | — | 3,574 individuals, 47.0 % Male samples |
Mean = 51.9 years Sd = 8.1 years |
African unspecified | Nigerian | UKB | — |
| PSS010514 | — | — | 5,886 individuals, 55.0 % Male samples |
Mean = 53.3 years Sd = 8.4 years |
South Asian | Indian | UKB | — |
| PSS010262 | — | — | 2,221 individuals, 45.0 % Male samples |
Mean = 58.0 years Sd = 7.1 years |
European | Ashkenazi | UKB | — |
| PSS013916 | — | — | [ ,
46.21 % Male samples |
— | European (British, Irish) |
— | UKB | — |