Trait: alcohol dependence

Trait Information
Identifier MONDO_0007079
Description Physical and psychological dependence on alcohol. [NCIT: P378]
Trait category
Other disease
Synonyms 2 synonyms
  • alcohol dependence
  • alcoholism
Mapped terms 13 mapped terms
  • DOID:0050741
  • ICD9:303.90
  • ICD9:305.0
  • MEDGEN:1801
  • MESH:D000437
  • MESH:D010610
  • MESH:D019973
  • NCIT:C3325
  • NCIT:C93040
  • OMIM:103780
  • SCTID:66590003
  • UMLS:C0001973
  • icd11.foundation:1580466198

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002738
(PRS_AUD)
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Alcohol use disorder alcohol dependence 326,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002738/ScoringFiles/PGS002738.txt.gz
PGS002739
(PRS_gene)
 PGP000346 |
Lai D et al. Transl Psychiatry (2022)
 Alcohol use disorder alcohol dependence 858
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002739/ScoringFiles/PGS002739.txt.gz
PGS018961
(TPMI_317.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 15
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018961/ScoringFiles/PGS018961.txt.gz
PGS018962
(TPMI_317.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 939,838
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018962/ScoringFiles/PGS018962.txt.gz
PGS018963
(TPMI_317.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 25,361
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018963/ScoringFiles/PGS018963.txt.gz
PGS018964
(TPMI_317.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 983,785
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018964/ScoringFiles/PGS018964.txt.gz
PGS018965
(TPMI_317.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 1,013,582
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018965/ScoringFiles/PGS018965.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014841 PGS002738
(PRS_AUD)
 PSS009911|
European Ancestry|
7,900 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder β: 3.17 (1.87) — Odds Ratio (OR top 10% vs rest): 1.96 [1.54, 2.51] — —
PPM014839 PGS002738
(PRS_AUD)
 PSS009910|
European Ancestry|
2,722 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals with unknown family history of AUD β: 2.91 (0.38) — Odds Ratio (OR top 10% vs rest): 1.5 [0.98, 2.29] — —
PPM014838 PGS002738
(PRS_AUD)
 PSS009909|
European Ancestry|
4,842 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals with family history of AUD β: 2.43 (0.6) — Odds Ratio (OR top 10% vs rest): 1.86 [1.35, 2.56] — —
PPM014840 PGS002738
(PRS_AUD)
 PSS009908|
European Ancestry|
336 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals without family history of AUD β: 2.64 (0.47) — Odds Ratio (OR top 10% vs rest): 0.45 [0.12, 1.69] — —
PPM038515 PGS002738
(PRS_AUD)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.03016 — — — —
PPM014842 PGS002739
(PRS_gene)
 PSS009912|
African Ancestry|
6,315 individuals
 PGP000346 |
Lai D et al. Transl Psychiatry (2022)
 Reported Trait: Alcohol use disorder β: 0.17 (0.03) — Odds Ratio (OR top 10% vs rest): 1.76 [1.32, 2.34] — —
PPM038988 PGS002739
(PRS_gene)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.01289 — — — —
PPM037143 PGS018961
(TPMI_317.1_Lassosum2)
 PSS012859|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.79678 R²: 0.03346 sex, age, array, PCs 1-10 —
PPM037144 PGS018962
(TPMI_317.1_LDpred2)
 PSS012858|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.79624 R²: 0.03318 sex, age, array, PCs 1-10 —
PPM037145 PGS018963
(TPMI_317.1_MegaPRS)
 PSS012860|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.78241 R²: 0.02968 sex, age, array, PCs 1-10 —
PPM037146 PGS018964
(TPMI_317.1_PRS-CS)
 PSS012861|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.81585 R²: 0.03723 sex, age, array, PCs 1-10 —
PPM037147 PGS018965
(TPMI_317.1_SBayesR)
 PSS012862|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.79751 R²: 0.03342 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012861 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012862 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012858 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS009908 — —
[
  • 72 cases
  • , 107 controls
]
 — European — COGA —
PSS009909 — —
[
  • 2,531 cases
  • , 669 controls
]
 — European — COGA —
PSS009910 — —
[
  • 850 cases
  • , 840 controls
]
 — European — COGA —
PSS009911 — —
[
  • 3,451 cases
  • , 1,616 controls
]
,
48.0 % Male samples
 — European — COGA —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —
PSS009912 — —
[
  • 2,786 cases
  • , 3,529 controls
]
 — African American or Afro-Caribbean — COGA, SAGE, Yale-Penn —
PSS012859 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012860 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —