| Trait Information | |
| Identifier | OBA_1001086 | Trait category |
Other measurement
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000736 (PRS_QRS) |
PGP000144 | Tadros R et al. Eur Heart J (2019) |
QRS duration | QRS duration | 26 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000736/ScoringFiles/PGS000736.txt.gz |
| PGS001525 (GBE_INI12340) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
QRS duration | QRS duration | 401 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001525/ScoringFiles/PGS001525.txt.gz |
| PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
QRS duration | QRS duration | 1,967 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001948/ScoringFiles/PGS001948.txt.gz |
| PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
QRS duration | QRS duration | 471,172 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002166/ScoringFiles/PGS002166.txt.gz |
| PGS003529 (cont-decay-log_ECG_QRS_duration) |
PGP000457 | Ding Y et al. Nature (2023) |
QRS duration | QRS duration | 979,739 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003529/ScoringFiles/PGS003529.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001760 | PGS000736 (PRS_QRS) |
PSS000905| European Ancestry| 1,185 individuals |
PGP000144 | Tadros R et al. Eur Heart J (2019) |
Reported Trait: Ajmaline-induced Type I Brugada syndrome electrocardiogram | OR: 1.047 [1.031, 1.063] | — | — | — | — |
| PPM001753 | PGS000736 (PRS_QRS) |
PSS000906| European Ancestry| 1,193 individuals |
PGP000144 | Tadros R et al. Eur Heart J (2019) |
Reported Trait: QRS slope in non SCN5A mutation carriers | β: 0.93 (0.2) | — | Correlation coefficient (r): 0.14 | — | — |
| PPM001751 | PGS000736 (PRS_QRS) |
PSS000906| European Ancestry| 1,193 individuals |
PGP000144 | Tadros R et al. Eur Heart J (2019) |
Reported Trait: Baseline QRS in non SCN5A mutation carriers | — | — | Correlation coefficent (r): 0.15 | — | — |
| PPM001755 | PGS000736 (PRS_QRS) |
PSS000904| European Ancestry| 1,257 individuals |
PGP000144 | Tadros R et al. Eur Heart J (2019) |
Reported Trait: QRS slope | β: 0.8 (0.22) | — | — | — | — |
| PPM001756 | PGS000736 (PRS_QRS) |
PSS000903| European Ancestry| 295 individuals |
PGP000144 | Tadros R et al. Eur Heart J (2019) |
Reported Trait: QRS slope | β: 0.8 (0.22) | — | — | Age, SCN5A mutation | — |
| PPM005235 | PGS001525 (GBE_INI12340) |
PSS004806| African Ancestry| 203 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: QRS duration | — | — | R²: 0.20692 [0.18939, 0.22446] Incremental R2 (full-covars): 0.01284 PGS R2 (no covariates): 0.02209 [0.01502, 0.02915] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005236 | PGS001525 (GBE_INI12340) |
PSS004807| East Asian Ancestry| 102 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: QRS duration | — | — | R²: 0.199 [0.16514, 0.23286] Incremental R2 (full-covars): 0.01328 PGS R2 (no covariates): 0.00454 [-0.00181, 0.0109] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005237 | PGS001525 (GBE_INI12340) |
PSS004808| European Ancestry| 1,601 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: QRS duration | — | — | R²: 0.1428 [0.13475, 0.15084] Incremental R2 (full-covars): 0.02153 PGS R2 (no covariates): 0.01977 [0.01635, 0.02319] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005238 | PGS001525 (GBE_INI12340) |
PSS004809| South Asian Ancestry| 315 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: QRS duration | — | — | R²: 0.20988 [0.19385, 0.2259] Incremental R2 (full-covars): 0.00738 PGS R2 (no covariates): 0.00578 [0.00243, 0.00912] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005239 | PGS001525 (GBE_INI12340) |
PSS004810| European Ancestry| 5,223 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: QRS duration | — | — | R²: 0.11697 [0.11241, 0.12153] Incremental R2 (full-covars): 0.01872 PGS R2 (no covariates): 0.02164 [0.01947, 0.02382] |
age, sex, UKB array type, Genotype PCs | — |
| PPM010461 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS008759| European Ancestry| 487 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2468 [0.1596, 0.3301] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010459 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS009431| European Ancestry| 1,702 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2202 [0.1743, 0.2652] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010462 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS008533| Greater Middle Eastern Ancestry| 50 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.1933 [-0.1794, 0.5176] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010463 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS008311| South Asian Ancestry| 305 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2407 [0.1281, 0.3472] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010464 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS008088| East Asian Ancestry| 137 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.0168 [-0.1652, 0.1978] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010465 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS007875| African Ancestry| 77 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.155 [-0.11, 0.3995] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010466 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS008979| African Ancestry| 140 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.0017 [-0.1776, 0.1809] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010460 | PGS001948 (portability-PLR_log_ECG_QRS_duration) |
PSS009205| European Ancestry| 329 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.1602 [0.0495, 0.267] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012175 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS009431| European Ancestry| 1,702 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2257 [0.1798, 0.2706] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012176 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS009205| European Ancestry| 329 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.1797 [0.0695, 0.2855] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012177 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS008759| European Ancestry| 487 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2307 [0.143, 0.3149] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012178 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS008533| Greater Middle Eastern Ancestry| 50 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2134 [-0.1591, 0.5327] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012179 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS008311| South Asian Ancestry| 305 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.2354 [0.1226, 0.3422] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012180 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS008088| East Asian Ancestry| 137 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.0367 [-0.1458, 0.2168] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012181 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS007875| African Ancestry| 77 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.1029 [-0.162, 0.354] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012182 | PGS002166 (portability-ldpred2_log_ECG_QRS_duration) |
PSS008979| African Ancestry| 140 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: QRS duration | — | — | Partial Correlation (partial-r): 0.0257 [-0.1542, 0.204] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM017457 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010893| European Ancestry| 1,567 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM017541 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010809| European Ancestry| 299 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM017625 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010641| European Ancestry| 400 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM017709 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010557| Greater Middle Eastern Ancestry| 42 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.04 | sex, age, deprivation index, PC1-16 | — |
| PPM017793 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010221| European Ancestry| 186 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.02 | sex, age, deprivation index, PC1-16 | — |
| PPM017961 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010389| East Asian Ancestry| 115 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.01 | sex, age, deprivation index, PC1-16 | — |
| PPM018129 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010725| African Ancestry| 116 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.02 | sex, age, deprivation index, PC1-16 | — |
| PPM017877 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010473| South Asian Ancestry| 253 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.04 | sex, age, deprivation index, PC1-16 | — |
| PPM018045 | PGS003529 (cont-decay-log_ECG_QRS_duration) |
PSS010305| African Ancestry| 67 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: QRS duration | — | — | partial-R2: 0.0 | sex, age, deprivation index, PC1-16 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS004806 | — | — | 203 individuals | — | African unspecified | — | UKB | — |
| PSS004807 | — | — | 102 individuals | — | East Asian | — | UKB | — |
| PSS004808 | — | — | 1,601 individuals | — | European | non-white British ancestry | UKB | — |
| PSS004809 | — | — | 315 individuals | — | South Asian | — | UKB | — |
| PSS004810 | — | — | 5,223 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS000903 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.14 | — | 295 individuals | — | European | — | Amsterdam | — |
| PSS000904 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.12 | — | 1,257 individuals | — | European | — | Amsterdam | — |
| PSS000905 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.15 | — | 1,185 individuals | — | European | — | Amsterdam | — |
| PSS000906 | Intravenous ajmaline was administered at consecutive boluses of 10 mg/min. A 10-s ECG was recorded ∼1 min after each bolus using a GE Healthcare electrocardiograph. The test was stopped when the target dose of 1 mg/kg rounded up to the next 10 mg was reached, if ventricular arrhythmia occurred, or at the manifestation of a Type I BrS pattern, defined as an ST elevation >2 mm with a coved morphology in any lead among V1–V2 in the 2nd to 4th intercostal spaces.13 | — | 1,193 individuals | — | European | — | Amsterdam | — |
| PSS009431 | — | — | 1,702 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS008533 | — | — | 50 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS010809 | — | — | 299 individuals, 38.0 % Male samples |
Mean = 52.9 years Sd = 6.6 years |
European | Polish | UKB | — |
| PSS010557 | — | — | 42 individuals, 62.0 % Male samples |
Mean = 53.8 years Sd = 6.7 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
| PSS010305 | — | — | 67 individuals, 30.0 % Male samples |
Mean = 49.8 years Sd = 6.5 years |
African American or Afro-Caribbean | Caribbean | UKB | — |
| PSS009205 | — | — | 329 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS008311 | — | — | 305 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS010725 | — | — | 116 individuals, 55.0 % Male samples |
Mean = 49.4 years Sd = 6.7 years |
African unspecified | Nigerian | UKB | — |
| PSS010473 | — | — | 253 individuals, 66.0 % Male samples |
Mean = 51.4 years Sd = 7.9 years |
South Asian | Indian | UKB | — |
| PSS008979 | — | — | 140 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS010221 | — | — | 186 individuals, 55.0 % Male samples |
Mean = 56.5 years Sd = 6.4 years |
European | Ashkenazi | UKB | — |
| PSS008088 | — | — | 137 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS010893 | — | — | 1,567 individuals, 50.0 % Male samples |
Mean = 55.5 years Sd = 7.4 years |
European | white British | UKB | — |
| PSS008759 | — | — | 487 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS010641 | — | — | 400 individuals, 47.0 % Male samples |
Mean = 53.6 years Sd = 7.5 years |
European | Italian | UKB | — |
| PSS010389 | — | — | 115 individuals, 35.0 % Male samples |
Mean = 51.1 years Sd = 6.9 years |
East Asian | Chinese | UKB | — |
| PSS007875 | — | — | 77 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |