| Trait Information | |
| Identifier | OBA_2050062 |
| Description | The amount of a alanine aminotransferase when measured in blood serum. [AUTO: patterns/patterns/entity_attribute_location] | Trait category |
Other measurement
|
| Synonyms |
3 synonyms
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000668 (snpnet.Alanine_aminotransferase) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Alanine aminotransferase [U/L] | serum alanine aminotransferase amount | 12,076 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000668/ScoringFiles/PGS000668.txt.gz |
| PGS000816 (GRS150_ALT) |
PGP000201 | Pazoki R et al. Nat Commun (2021) |
Alanine transaminase | serum alanine aminotransferase amount | 150 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000816/ScoringFiles/PGS000816.txt.gz | |
| PGS001940 (portability-PLR_log_ALT) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Alanine aminotransferase | serum alanine aminotransferase amount | 51,849 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001940/ScoringFiles/PGS001940.txt.gz |
| PGS002158 (portability-ldpred2_log_ALT) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Alanine aminotransferase | serum alanine aminotransferase amount | 774,274 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002158/ScoringFiles/PGS002158.txt.gz |
| PGS002732 (GRS_77) |
PGP000341 | Vujkovic M et al. Nat Genet (2022) |
Chronic elevation of alanine aminotransferase | serum alanine aminotransferase amount | 77 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002732/ScoringFiles/PGS002732.txt.gz |
| PGS003342 (CVGRS_ALT) |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Alanine aminotransferase level | serum alanine aminotransferase amount | 51 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003342/ScoringFiles/PGS003342.txt.gz |
| PGS003351 (ALLGRS_ALT) |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Alanine aminotransferase level | serum alanine aminotransferase amount | 57 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003351/ScoringFiles/PGS003351.txt.gz |
| PGS003522 (cont-decay-log_ALT) |
PGP000457 | Ding Y et al. Nature (2023) |
Alanine aminotransferase | serum alanine aminotransferase amount | 979,739 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003522/ScoringFiles/PGS003522.txt.gz |
| PGS004329 (X30620.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Alanine aminotransferase (U/L) | serum alanine aminotransferase amount | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004329/ScoringFiles/PGS004329.txt.gz |
| PGS004715 (ALT_PRSmix_eur) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Alanine aminotransferase | serum alanine aminotransferase amount | 559,731 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004715/ScoringFiles/PGS004715.txt.gz |
| PGS004716 (ALT_PRSmix_sas) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Alanine aminotransferase | serum alanine aminotransferase amount | 2,283,693 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004716/ScoringFiles/PGS004716.txt.gz |
| PGS004717 (ALT_PRSmixPlus_eur) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Alanine aminotransferase | serum alanine aminotransferase amount | 1,051,633 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004717/ScoringFiles/PGS004717.txt.gz |
| PGS004718 (ALT_PRSmixPlus_sas) |
PGP000604 | Truong B et al. Cell Genom (2024) |
Alanine aminotransferase | serum alanine aminotransferase amount | 2,283,693 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004718/ScoringFiles/PGS004718.txt.gz |
| PGS019789 (TPMI_ALT_Lassosum2) |
PGP000835 | Chen HH et al. Nature (2025) |
Serum glutamate pyruvate transaminase | serum alanine aminotransferase amount | 15,260 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019789/ScoringFiles/PGS019789.txt.gz | |
| PGS019813 (TPMI_ALT_LDPred2) |
PGP000835 | Chen HH et al. Nature (2025) |
Serum glutamate pyruvate transaminase | serum alanine aminotransferase amount | 939,836 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019813/ScoringFiles/PGS019813.txt.gz | |
| PGS019837 (TPMI_ALT_PRS-CS) |
PGP000835 | Chen HH et al. Nature (2025) |
Serum glutamate pyruvate transaminase | serum alanine aminotransferase amount | 983,787 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019837/ScoringFiles/PGS019837.txt.gz | |
| PGS019861 (TPMI_ALT_SBayesR) |
PGP000835 | Chen HH et al. Nature (2025) |
Serum glutamate pyruvate transaminase | serum alanine aminotransferase amount | 143,622 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019861/ScoringFiles/PGS019861.txt.gz | |
| PGS019885 (TPMI_ALT_MegaPRS) |
PGP000835 | Chen HH et al. Nature (2025) |
Serum glutamate pyruvate transaminase | serum alanine aminotransferase amount | 367,008 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019885/ScoringFiles/PGS019885.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001466 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS000624| European Ancestry| 23,569 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alanine aminotransferase [U/L] | — | — | R²: 0.2041 Spearman's ρ: 0.22 |
Age, sex, PCs(1-40) | — |
| PPM001501 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS000625| South Asian Ancestry| 7,325 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alanine aminotransferase [U/L] | — | — | R²: 0.18304 Spearman's ρ: 0.198 |
Age, sex, PCs(1-40) | — |
| PPM001536 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS000626| European Ancestry| 63,766 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alanine aminotransferase [U/L] | — | — | R²: 0.19165 Spearman's ρ: 0.244 |
Age, sex, PCs(1-40) | — |
| PPM001396 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS000622| African Ancestry| 6,017 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alanine aminotransferase [U/L] | — | — | R²: 0.17646 Spearman's ρ: 0.092 |
Age, sex, PCs(1-40) | — |
| PPM001431 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS000623| East Asian Ancestry| 1,081 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Alanine aminotransferase [U/L] | — | — | R²: 0.1561 Spearman's ρ: 0.145 |
Age, sex, PCs(1-40) | — |
| PPM007267 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS007078| European Ancestry| 23,758 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: Alanine aminotransferase | — | — | R²: 0.07978 [0.07332, 0.08623] Incremental R2 (full-covars): 0.00218 PGS R2 (no covariates): 0.03 [0.02583, 0.03418] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007265 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS007076| African Ancestry| 6,099 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: Alanine aminotransferase | — | — | R²: 0.0977 [0.084, 0.11141] Incremental R2 (full-covars): 0.00077 PGS R2 (no covariates): 0.00447 [0.00124, 0.00771] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007266 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS007077| East Asian Ancestry| 1,615 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: Alanine aminotransferase | — | — | R²: 0.08994 [0.06408, 0.11581] Incremental R2 (full-covars): 0.00177 PGS R2 (no covariates): 0.02382 [0.00954, 0.03809] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007268 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS007079| South Asian Ancestry| 7,414 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: Alanine aminotransferase | — | — | R²: 0.08504 [0.07323, 0.09685] Incremental R2 (full-covars): 0.00213 PGS R2 (no covariates): 0.02862 [0.02135, 0.0359] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007269 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS007080| European Ancestry| 64,440 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |Ext. |
Reported Trait: Alanine aminotransferase | — | — | R²: 0.06901 [0.06532, 0.0727] Incremental R2 (full-covars): 0.00284 PGS R2 (no covariates): 0.03994 [0.03705, 0.04284] |
age, sex, UKB array type, Genotype PCs | — |
| PPM038753 | PGS000668 (snpnet.Alanine_aminotransferase) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.01835 | — | — | — | — |
| PPM002176 | PGS000816 (GRS150_ALT) |
PSS001062| European Ancestry| 3,620 individuals |
PGP000201 | Pazoki R et al. Nat Commun (2021) |
Reported Trait: Serum alanine transaminase level | OR: 1.72 [1.36, 2.07] | — | — | — | — |
| PPM002173 | PGS000816 (GRS150_ALT) |
PSS001060| European Ancestry| 331 individuals |
PGP000201 | Pazoki R et al. Nat Commun (2021) |
Reported Trait: Serum alanine transaminase level | β: 3.09 [2.02, 4.17] | — | — | — | Unit of measurement = U/L in alanine transaminase |
| PPM010396 | PGS001940 (portability-PLR_log_ALT) |
PSS009201| European Ancestry| 3,950 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2328 [0.203, 0.2622] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010397 | PGS001940 (portability-PLR_log_ALT) |
PSS008755| European Ancestry| 6,321 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2248 [0.2012, 0.2481] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010399 | PGS001940 (portability-PLR_log_ALT) |
PSS008307| South Asian Ancestry| 5,992 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2205 [0.1963, 0.2445] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010400 | PGS001940 (portability-PLR_log_ALT) |
PSS008084| East Asian Ancestry| 1,716 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.1841 [0.1377, 0.2297] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010401 | PGS001940 (portability-PLR_log_ALT) |
PSS007871| African Ancestry| 2,345 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.1008 [0.0604, 0.1409] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010402 | PGS001940 (portability-PLR_log_ALT) |
PSS008975| African Ancestry| 3,656 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.1054 [0.0731, 0.1374] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010395 | PGS001940 (portability-PLR_log_ALT) |
PSS009427| European Ancestry| 18,995 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2633 [0.25, 0.2765] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010398 | PGS001940 (portability-PLR_log_ALT) |
PSS008529| Greater Middle Eastern Ancestry| 1,123 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.1871 [0.1295, 0.2435] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM038771 | PGS001940 (portability-PLR_log_ALT) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.01765 | — | — | — | — |
| PPM012112 | PGS002158 (portability-ldpred2_log_ALT) |
PSS009201| European Ancestry| 3,950 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2355 [0.2058, 0.2648] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012111 | PGS002158 (portability-ldpred2_log_ALT) |
PSS009427| European Ancestry| 18,995 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2622 [0.2489, 0.2754] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012113 | PGS002158 (portability-ldpred2_log_ALT) |
PSS008755| European Ancestry| 6,321 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2258 [0.2022, 0.2491] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012114 | PGS002158 (portability-ldpred2_log_ALT) |
PSS008529| Greater Middle Eastern Ancestry| 1,123 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.1997 [0.1423, 0.2557] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012115 | PGS002158 (portability-ldpred2_log_ALT) |
PSS008307| South Asian Ancestry| 5,992 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.2086 [0.1842, 0.2328] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012116 | PGS002158 (portability-ldpred2_log_ALT) |
PSS008084| East Asian Ancestry| 1,716 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.194 [0.1478, 0.2394] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012117 | PGS002158 (portability-ldpred2_log_ALT) |
PSS007871| African Ancestry| 2,345 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.1063 [0.0659, 0.1463] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012118 | PGS002158 (portability-ldpred2_log_ALT) |
PSS008975| African Ancestry| 3,656 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Alanine aminotransferase | — | — | Partial Correlation (partial-r): 0.088 [0.0557, 0.1202] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM038777 | PGS002158 (portability-ldpred2_log_ALT) |
PSS013916| European Ancestry| 425,240 individuals |
PGP000865 | Bhatt IS et al. J Assoc Res Otolaryngol (2024) |Ext. |
Reported Trait: Age-related hearing difficulty | β: 0.01742 | — | — | — | — |
| PPM014820 | PGS002732 (GRS_77) |
PSS009901| Multi-ancestry (including European)| 45,007 individuals |
PGP000341 | Vujkovic M et al. Nat Genet (2022) |
Reported Trait: Non-alcoholic fatty liver disease | — | — | Risk difference: 0.604 [0.418, 0.79] | age, gender, 3-5 ancestry PCs | — |
| PPM022311 | PGS002732 (GRS_77) |
PSS011911| Multi-ancestry (including European)| 48,603 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |Ext. |
Reported Trait: non-alcoholic fattly liver disease | OR: 1.31 [1.21, 1.41] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM022322 | PGS002732 (GRS_77) |
PSS011912| European Ancestry| 45,356 individuals |
PGP000701 | Loesch DP et al. Nat Commun (2025) |Ext. |
Reported Trait: non-alcoholic fattly liver disease | OR: 1.31 [1.21, 1.42] | — | — | age, age^2, sex, UKB centre, array, genetic PCS 1-20 | — |
| PPM016181 | PGS003342 (CVGRS_ALT) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Alanine aminotransferase level | β: 0.1213 | — | — | — | — |
| PPM016198 | PGS003342 (CVGRS_ALT) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Type 2 diabetes | OR: 1.04754 | — | — | — | — |
| PPM016190 | PGS003351 (ALLGRS_ALT) |
PSS010055| East Asian Ancestry| 22,608 individuals |
PGP000405 | Kim YJ et al. Nat Commun (2022) |
Reported Trait: Alanine aminotransferase level | β: 0.16161 | — | — | — | — |
| PPM017450 | PGS003522 (cont-decay-log_ALT) |
PSS010885| European Ancestry| 19,106 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.07 | sex, age, deprivation index, PC1-16 | — |
| PPM017534 | PGS003522 (cont-decay-log_ALT) |
PSS010801| European Ancestry| 3,939 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.05 | sex, age, deprivation index, PC1-16 | — |
| PPM017702 | PGS003522 (cont-decay-log_ALT) |
PSS010549| Greater Middle Eastern Ancestry| 1,094 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.04 | sex, age, deprivation index, PC1-16 | — |
| PPM017786 | PGS003522 (cont-decay-log_ALT) |
PSS010213| European Ancestry| 2,238 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.07 | sex, age, deprivation index, PC1-16 | — |
| PPM017870 | PGS003522 (cont-decay-log_ALT) |
PSS010465| South Asian Ancestry| 5,938 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.04 | sex, age, deprivation index, PC1-16 | — |
| PPM017954 | PGS003522 (cont-decay-log_ALT) |
PSS010381| East Asian Ancestry| 1,705 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM018038 | PGS003522 (cont-decay-log_ALT) |
PSS010297| African Ancestry| 2,333 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.01 | sex, age, deprivation index, PC1-16 | — |
| PPM018122 | PGS003522 (cont-decay-log_ALT) |
PSS010717| African Ancestry| 3,627 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.01 | sex, age, deprivation index, PC1-16 | — |
| PPM017618 | PGS003522 (cont-decay-log_ALT) |
PSS010633| European Ancestry| 6,169 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Alanine aminotransferase | — | — | partial-R2: 0.05 | sex, age, deprivation index, PC1-16 | — |
| PPM020444 | PGS004329 (X30620.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Alanine aminotransferase (U/L) | — | — | PGS R2 (no covariates): 0.17221 | — | — |
| PPM020940 | PGS004715 (ALT_PRSmix_eur) |
PSS011457| European Ancestry| 5,247 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Alanine aminotransferase | — | — | Incremental R2 (Full model versus model with only covariates): 0.013 [0.007, 0.019] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM020941 | PGS004716 (ALT_PRSmix_sas) |
PSS011458| South Asian Ancestry| 6,794 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Alanine aminotransferase | — | — | Incremental R2 (Full model versus model with only covariates): 0.03 [0.022, 0.038] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM020942 | PGS004717 (ALT_PRSmixPlus_eur) |
PSS011457| European Ancestry| 5,247 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Alanine aminotransferase | — | — | Incremental R2 (Full model versus model with only covariates): 0.041 [0.03, 0.052] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM020943 | PGS004718 (ALT_PRSmixPlus_sas) |
PSS011458| South Asian Ancestry| 6,794 individuals |
PGP000604 | Truong B et al. Cell Genom (2024) |
Reported Trait: Alanine aminotransferase | — | — | Incremental R2 (Full model versus model with only covariates): 0.031 [0.023, 0.039] | age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 | Incremental R2 (Full model versus model with only covariates) |
| PPM037971 | PGS019789 (TPMI_ALT_Lassosum2) |
PSS013691| East Asian Ancestry| 14,357 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Serum glutamate pyruvate transaminase | — | AUROC: 0.57287 | R²: 0.04167 | sex, age, array, PCs 1-10 | — |
| PPM037995 | PGS019813 (TPMI_ALT_LDPred2) |
PSS013690| East Asian Ancestry| 14,357 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Serum glutamate pyruvate transaminase | — | AUROC: 0.78939 | R²: 0.04462 | sex, age, array, PCs 1-10 | — |
| PPM038019 | PGS019837 (TPMI_ALT_PRS-CS) |
PSS013693| East Asian Ancestry| 14,357 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Serum glutamate pyruvate transaminase | — | AUROC: 0.67402 | R²: 0.04349 | sex, age, array, PCs 1-10 | — |
| PPM038043 | PGS019861 (TPMI_ALT_SBayesR) |
PSS013694| East Asian Ancestry| 14,357 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Serum glutamate pyruvate transaminase | — | — | R²: 0.0322 | sex, age, array, PCs 1-10 | — |
| PPM038067 | PGS019885 (TPMI_ALT_MegaPRS) |
PSS013692| East Asian Ancestry| 14,357 individuals |
PGP000835 | Chen HH et al. Nature (2025) |
Reported Trait: Serum glutamate pyruvate transaminase | — | — | R²: 0.03914 | sex, age, array, PCs 1-10 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS013693 | — | — | 14,357 individuals, 46.65 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013694 | — | — | 14,357 individuals, 46.65 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS008529 | — | — | 1,123 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS011457 | — | — | 5,247 individuals | — | European | — | AllofUs | — |
| PSS009427 | — | — | 18,995 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS011458 | — | — | 6,794 individuals | — | South Asian | — | G&H | — |
| PSS010055 | — | — | 22,608 individuals | — | East Asian | — | KBA, KoGES | — |
| PSS010801 | — | — | 3,939 individuals, 38.0 % Male samples |
Mean = 54.4 years Sd = 7.5 years |
European | Polish | UKB | — |
| PSS010549 | — | — | 1,094 individuals, 60.0 % Male samples |
Mean = 51.9 years Sd = 7.9 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
| PSS010297 | — | — | 2,333 individuals, 37.0 % Male samples |
Mean = 52.5 years Sd = 8.1 years |
African American or Afro-Caribbean | Caribbean | UKB | — |
| PSS009201 | — | — | 3,950 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS008307 | — | — | 5,992 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS010717 | — | — | 3,627 individuals, 46.0 % Male samples |
Mean = 51.9 years Sd = 8.1 years |
African unspecified | Nigerian | UKB | — |
| PSS010465 | — | — | 5,938 individuals, 54.0 % Male samples |
Mean = 53.3 years Sd = 8.4 years |
South Asian | Indian | UKB | — |
| PSS000622 | — | — | 6,017 individuals | — | African unspecified | — | UKB | — |
| PSS000623 | — | — | 1,081 individuals | — | East Asian | — | UKB | — |
| PSS000624 | — | — | 23,569 individuals | — | European | Non-British White | UKB | — |
| PSS000625 | — | — | 7,325 individuals | — | South Asian | — | UKB | — |
| PSS000626 | — | — | 63,766 individuals | — | European (British) |
— | UKB | — |
| PSS008975 | — | — | 3,656 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS011911 | ICD10: E11 for T2D, N18 for CKD, first occurence of I20-125 for CAD. BMI: baseline body mass index | Median = 14.8 years | 48,603 individuals, 46.0 % Male samples |
Mean = 56.8 years Sd = 8.2 years |
European, East Asian, South Asian, Hispanic or Latin American, African unspecified | — | UKB | — |
| PSS011912 | ICD10: E11 for T2D, N18 for CKD, first occurence of I20-125 for CAD, K76.0 for NAFLD. BMI: baseline body mass index | Median = 14.8 years | 45,356 individuals, 46.0 % Male samples |
Mean = 57.1 years Sd = 8.1 years |
European | — | UKB | — |
| PSS010213 | — | — | 2,238 individuals, 45.0 % Male samples |
Mean = 58.1 years Sd = 7.1 years |
European | Ashkenazi | UKB | — |
| PSS008084 | — | — | 1,716 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS009901 | — | — | [
|
— | European | U.S. | BioVU, CAP, EPOS | PIVENS, FLINT, NASH |
| PSS009901 | — | — | [
|
— | Hispanic or Latin American | U.S. | NR | LQTS, NASH |
| PSS007076 | — | — | 6,099 individuals | — | African unspecified | — | UKB | — |
| PSS007077 | — | — | 1,615 individuals | — | East Asian | — | UKB | — |
| PSS007078 | — | — | 23,758 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007079 | — | — | 7,414 individuals | — | South Asian | — | UKB | — |
| PSS007080 | — | — | 64,440 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS001062 | Serum concentrations of alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were measured from stored blood samples using the enzymatic rate analytical method on a Beckman Coulter AU5800. The manufacturer’s analytic range for ALT was 3–500 U/L, for ALP, 5–1500 U/L, and it was 5–1200 U/L for GGT. | — | 3,620 individuals | — | European | — | NFBC | — |
| PSS001060 | Serum concentrations of alanine transaminase (ALT) and alkaline phosphatase (ALP), were measured from stored blood samples using the enzymatic rate analytical method on a Beckman Coulter AU5800. The manufacturer’s analytic range for ALT was 3–500 U/L, for ALP, 5–1500 U/L, and it was 5–1200 U/L for GGT. | — | 331 individuals | — | European | — | Airwave | — |
| PSS008755 | — | — | 6,321 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS010885 | — | — | 19,106 individuals, 46.0 % Male samples |
Mean = 56.9 years Sd = 7.9 years |
European | white British | UKB | — |
| PSS010381 | — | — | 1,705 individuals, 33.0 % Male samples |
Mean = 52.4 years Sd = 7.8 years |
East Asian | Chinese | UKB | — |
| PSS010633 | — | — | 6,169 individuals, 45.0 % Male samples |
Mean = 54.5 years Sd = 8.4 years |
European | Italian | UKB | — |
| PSS007871 | — | — | 2,345 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS013916 | — | — | [ ,
46.21 % Male samples |
— | European (British, Irish) |
— | UKB | — |
| PSS013690 | — | — | 14,357 individuals, 46.65 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013691 | — | — | 14,357 individuals, 46.65 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |
| PSS013692 | — | — | 14,357 individuals, 46.65 % Male samples |
— | East Asian (Han Chinese) |
— | TPMI | — |