Trait: reproductive behavior trait

Trait Information
Identifier OBA_2050117
Description The characteristic of a reproductive behavior. [obo: oba/patterns/entity_attribute_part_of]
Trait category
Other measurement
Synonym characteristic of reproductive behavior

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002317
(repro_ChildLess.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002317/ScoringFiles/PGS002317.txt.gz
PGS002389
(repro_ChildLess.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 1,578
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002389/ScoringFiles/PGS002389.txt.gz
PGS002438
(repro_ChildLess.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 10,891
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002438/ScoringFiles/PGS002438.txt.gz
PGS002487
(repro_ChildLess.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 86,054
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002487/ScoringFiles/PGS002487.txt.gz
PGS002536
(repro_ChildLess.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 53
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002536/ScoringFiles/PGS002536.txt.gz
PGS002585
(repro_ChildLess.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002585/ScoringFiles/PGS002585.txt.gz
PGS002634
(repro_ChildLess.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 176,147
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002634/ScoringFiles/PGS002634.txt.gz
PGS002683
(repro_ChildLess.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Childless reproductive behavior trait 954,898
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002683/ScoringFiles/PGS002683.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013082 PGS002317
(repro_ChildLess.BOLT-LMM)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0026 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013131 PGS002317
(repro_ChildLess.BOLT-LMM)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0066 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013180 PGS002317
(repro_ChildLess.BOLT-LMM)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0058 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013229 PGS002317
(repro_ChildLess.BOLT-LMM)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM038470 PGS002317
(repro_ChildLess.BOLT-LMM)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.03559 — — — —
PPM013370 PGS002389
(repro_ChildLess.P+T.0.0001)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013419 PGS002389
(repro_ChildLess.P+T.0.0001)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0032 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013468 PGS002389
(repro_ChildLess.P+T.0.0001)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013517 PGS002389
(repro_ChildLess.P+T.0.0001)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013566 PGS002438
(repro_ChildLess.P+T.0.001)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013664 PGS002438
(repro_ChildLess.P+T.0.001)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013713 PGS002438
(repro_ChildLess.P+T.0.001)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013615 PGS002438
(repro_ChildLess.P+T.0.001)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM039055 PGS002438
(repro_ChildLess.P+T.0.001)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.20085 — — — —
PPM013762 PGS002487
(repro_ChildLess.P+T.0.01)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013811 PGS002487
(repro_ChildLess.P+T.0.01)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013860 PGS002487
(repro_ChildLess.P+T.0.01)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013909 PGS002487
(repro_ChildLess.P+T.0.01)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM038638 PGS002487
(repro_ChildLess.P+T.0.01)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.5959 — — — —
PPM013958 PGS002536
(repro_ChildLess.P+T.1e-06)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014007 PGS002536
(repro_ChildLess.P+T.1e-06)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014056 PGS002536
(repro_ChildLess.P+T.1e-06)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014105 PGS002536
(repro_ChildLess.P+T.1e-06)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014252 PGS002585
(repro_ChildLess.P+T.5e-08)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014154 PGS002585
(repro_ChildLess.P+T.5e-08)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014203 PGS002585
(repro_ChildLess.P+T.5e-08)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014301 PGS002585
(repro_ChildLess.P+T.5e-08)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014399 PGS002634
(repro_ChildLess.PolyFun-pred)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0066 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_ChildLess.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014448 PGS002634
(repro_ChildLess.PolyFun-pred)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0045 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_ChildLess.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014497 PGS002634
(repro_ChildLess.PolyFun-pred)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0022 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_ChildLess.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014350 PGS002634
(repro_ChildLess.PolyFun-pred)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_ChildLess.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM038695 PGS002634
(repro_ChildLess.PolyFun-pred)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.0215 — — — —
PPM014546 PGS002683
(repro_ChildLess.SBayesR)
 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0023 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014595 PGS002683
(repro_ChildLess.SBayesR)
 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0043 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014644 PGS002683
(repro_ChildLess.SBayesR)
 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0053 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014693 PGS002683
(repro_ChildLess.SBayesR)
 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0016 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM038462 PGS002683
(repro_ChildLess.SBayesR)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: -0.0371 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009711 — — 6,193 individuals — African unspecified — UKB —
PSS009712 — — 909 individuals — East Asian — UKB —
PSS009713 — — 43,069 individuals — European Non-British European UKB —
PSS009714 — — 7,846 individuals — South Asian — UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —